Objective: To analyzed the variation of uric acid (UA) traits in different Hoehn-Yahr staging in Parkinson’s disease (PD).

Background: PD is a common neurodegenerative disease. Oxidative stress is one of the important factors in the pathogenesis of PD. UA, as a physiological antioxidant, has effects of scavenging free radicals.

Method: A total of 344 patients with PD who were admitted in our hospital between 2015 and 2019 were retrospectively reviewed. According to Hoehn-Yahr（H-Y）staging, PD patients were divided into early, medium and advanced stage. UA value was compared in each group. Then, multiple linear regression analysis was used to analyze the relationship between uric acid and age, dopamine dosage, body weight(BMI)

Results: UA value in the early stage was higher than in the medium and advanced stages, and the differences were statistically significant (t=5.959,P<0.0001; and t=7.320, P<0.0001, respectively). UA value in the medium stage was higher than that in the advanced stage (t = 3.874, P=0.0003). With the aggravation of the disease, the uric acid value of each stage shows a downward trend. There was a linear relationship between uric acid and dopamine dosage, weight, and a negative correlation between uric acid and dopamine dosage, and a positive correlation with body weight.

Conclusion: UA value can be considered as potential biomarkers for monitoring of PD patients, It can also be used as a potential neuroprotective agent for PD treatment.In view of the relationship between UA, dopamine dosage and weight, it is suggested that weight management and drug management are important for PD treatment.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/clinical-research-of-serum-uric-acid-levels-in-parkinsons-disease/