Session Information
Date: Tuesday, June 21, 2016
Session Title: Tics/Stereotypies
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To investigate whether children with tics reveal features of additional hyperkinetic movement disorders.
Background: The patho-physiology for idiopathic tic disorders is unknown, although underlying alterations within cortico-striatal-thalamo-cortical circuits appear likely. Regarding suspected inhibitory input from the basal ganglia, we aimed to phenotype other concurrent movement disorders that could contribute to the idiopathic pediatric tic spectrum.
Methods: In 30 children (aged 4-17 years) with idiopathic tics, we recorded standardized motor behavior according to ataxia, dystonia and chorea rating scales [Scale for Assessment and Rating of Ataxia (SARA), Burke Fahn Marsden Movement Scale (BFMMS), and Dyskinesia Impairment Scale (DIS)]. A panel of 5 (pediatric) neurologists phenotyped motor behavior. A separate panel of 3 pediatric neurologists and 3 MD/PhD researchers quantified motor behavior according to the SARA, BFMMS and DIS.
Results: 9 of 30 children were phenotyped with concurrent hyperkinetic movement disorders (≥2/5 assessors; chorea n=4, dystonia n=2 and myoclonus n=3). After age-correction, regression analysis showed that the choreatic phenotypic subgroup revealed significantly higher total BFMMS and DIS scores: (p=0.045, β=0.31 and p=0.014, β=0.43, respectively), than the group without concurrent movement disorders. One child without any concurrent movement disorders during the analysis revealed additional chorea two months later. Ataxia appeared unrelated with tics.
Conclusions: About 30% of children with idiopathic tics can reveal other features of hyperkinetic movement disorders. Systematic phenotypic assessment of specified pediatric tic subgroups may contribute to genetic studies on underlying (modifying) gene defects .
The abstract was submitted to the International Child Neurology Congress (ICNC); from may 1st – 5th 2016 in Amsterdam, the Netherlands.
To cite this abstract in AMA style:
P.F. Sinnige, R. Brandsma, W. Eggink, M.J. Kuiper, I.J. Lunsing, M. Boon, C.C.S. Delnooz, M.E. van Egmond, O.G.F. Sinnige, J.J. de Vries, P.J. Hoekstra, D.A. Sival. Children with idiopathic tics reveal additional features of hyperkinetic movement disorders [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/children-with-idiopathic-tics-reveal-additional-features-of-hyperkinetic-movement-disorders/. Accessed May 13, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/children-with-idiopathic-tics-reveal-additional-features-of-hyperkinetic-movement-disorders/