Objective: To evaluate the characteristics of lower gastrointestinal tract dysfunction in patients with Parkinson disease (PD).

Background: Lower gastrointestinal tract dysfunction is common in patients with PD. Constipation is a prominent lower gastrointestinal tract dysfunction that occurs frequently in patients with PD. Usually, there are three types of constipation in according with the types of lower gastrointestinal tract dysfunction: colonic inertia type (slow-transit constipation), outlet obstruction type (pelvic floor dysfunction), and mixed type.  However, characteristics of constipation due to lower gastrointestinal tract dysfunction in patients with PD have been unknown.

Method: Nineteen patients with PD with motor fluctuations were recruited; those with other conditions that might have influenced lower gastrointestinal tract function were excluded.  We performed questionnaire of bowel symptom and colonic transit time (CTT) study.  The CTT study was performed using the repetitive ingestion method. We counted the number of markers in each segment of the large bowel and then calculated the right CTT, left CTT, rectosigmoid CTT, and total CTT.

Results: Seventeen patients with PD had constipation. Thirteen patients with PD (68.4%) mainly had outlet obstruction type (pelvic floor dysfunction), 6 (31.6.1%) mainly had colonic inertia type (slow-transit constipation).  However, most of them also had overlapped findings (nearly mixed type).

Conclusion: In patients with PD, constipation due to lower gastrointestinal tract function was common, in particular colonic inertia type (slow-transit constipation).

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MDS Abstracts - https://www.mdsabstracts.org/abstract/characteristics-of-lower-gastrointestinal-tract-dysfunction-in-patients-with-parkinson-disease/