Objective: This study aims to investigate the association between comprehensive blood lipid biomarkers and Parkinson’s disease (PD).

Background: Studies have shown that the serum levels of lipid markers were reduced in PD patients compared to non-PD subjects. Mild cognitive impairment (MCI) is commonly present in PD patients even at the time of diagnosis. It was previously reported that higher triglyceride(TG) level is significant associated with PD-MCI. In view of the potential neuroprotective effects of lipids in PD and limited evidence in this field, we conducted a cross-sectionals study to examine the association between lipids and PD and further explored the relationship between lipids and PD-MCI.

Method: A total of 205 PD patients and 102 non-PD subjects were included from Early Parkinson’s disease Longitudinal Singapore (PALS) cohort. We investigated 6 serum lipid  biomarkers including total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1(Apo A1), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (Apo B).  PD patients were further classified into mild cognitive impairment (MCI) and normal cognition (NC)  subgroups. We conducted a cross-sectionals study to examine the association between lipids and PD and further explored the relationship between lipids and PD-MCI.

Results: PD patients had significantly lower level of lipid panel including TC, TG, HDL-C, Apo A1, LDL-C and Apo B (all p < 0.05).  TC, TG, Apo A1  and  Apo B levels were independent protective factors (p < 0.05) for PD in the logistic regression model. PD-MCI group had significantly higher mean TC, TG levels and  Apo A1 levels compared to  PD-NC group. Higher  TC,  TG and Apo A1 levels were independent risk factors (P < 0.05) for PD-MCI .

Conclusion: We demonstrated that PD patients had significantly lower levels of lipid biomarkers while PD-MCI patients had higher levels of  TC,  TG  and Apo A1.  TC,  TG  and Apo A1 may be useful biomarkers for PD-MCI.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/blood-lipid-biomarkers-in-early-parkinson-disease-and-parkinson-disease-with-mild-cognitive-impairment/