Objective: This nationwide population-based, matched cohort study aimed to determine whether patients with PD have an increased risk of MI, stroke, and mortality by using data from the entire Korean population.

Background: Although epidemiologic studies have consistently reported an increase in mortality associated with Parkinson disease (PD), the relationship between cardiovascular disease (CVD)—the leading cause of death—and PD is unclear. In this nationwide study, we assessed the risk of myocardial infarction (MI), stroke, and all-cause mortality in patients with PD in Korea.

Method: A population-based, age- and sex-matched cohort study was conducted using the database from the Rare Intractable Disease registry and the Health Insurance Review and Assessment Service, which covers the entire Korean population, from 2010 to 2015. We analyzed 25 624 PD and 128 120 non-PD cases (≥40 years; mean age, 69.0 ± 10.2 years; 42.5% men) without previous diagnosis of MI or stroke. Survival analysis, log-rank test, and Cox proportional hazards regression models were used to calculate the incidence, survival rate, and hazard ratio of CVD and mortality.

Results: PD was significantly associated with the prospective development of MI (hazard ratio [HR]: 1.43, 95% confidence interval [CI]: 1.28–1.59), stroke (HR: 1.42, 95% CI: 1.31–1.54), and all-cause death (HR: 2.7, 95% CI: 2.60–2.81) after adjustment for multiple covariates during the 498 811.6 person-years of follow-up. The PD group had significantly lower 6-year MI- and stroke-free rates and survival rates than the non-PD group (log-rank p < 0.0001)

Conclusion: There is an increased risk of MI, stroke, and all-cause death in patients with PD. This finding has important implications for clinicians and supports the need for preventative measures for CVD in patients with PD.

References: 1. L.V. Kalia, A.E. Lang, Parkinson’s disease, Lancet 386 (2015) 896-912. 2. T.K. Khoo, A.J. Yarnall, G.W. Duncan, S. Coleman, J.T. O’Brien, D.J. Brooks, R.A. Barker, D.J. Burn, The spectrum of nonmotor symptoms in early Parkinson disease, Neurology 80 (2013) 276-281. 3. J.A. Driver, T. Kurth, J.E. Buring, J.M. Gaziano, G. Logroscino, Parkinson disease and risk of mortality: a prospective comorbidity-matched cohort study, Neurology 70 (2008) 1423-1430.

« Back to 2019 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/association-between-parkinson-disease-and-the-risk-of-cardiovascular-disease-and-all-cause-mortality-a-nationwide-register-based-cohort-study/