Objective: The Apo E allele frequencies were evaluated in Korean patients with probable PDD diagnosed by the MDS task force criteria for the diagnosis of PDD in this study.

Background: Background: It has been well known that the APOE ε4 allele is a strong risk factor in Alzheimer’s disease (AD) and occurs at an increased frequency in dementia with amyloid pathology. However The clinical significance of the apolipoprotein E (Apo E) ε4 allele in Parkinson’s disease dementia (PDD) with synucleinopathy has been a subject of debate. PDD is one of the second most common subtypes of dementia in Korean population. 

Methods:  Forty patients participated in the study, Twenty patients with PDD and 20 age matched healthy controls. The Apo E genotype was determined by the polymerase chain reaction (PCR) and allele specific hybridization using the Apo E typing test kit. Results: The Apo E ε4 allele frequency in the PDD group was 28% and was significantly higher than those of normal controls (15%).

Results: Results: The Apo E ε4 allele frequency in the PDD group was 28% and was significantly higher than those of normal controls (15%). Conclusions: These results that the elevated Apo E ε4 frequency in the PDD groups, in which the overall brain neuritic plaque burden was low, indicates that apoE ε4 might contribute to neurodegeneration through mechanisms unrelated to amyloid processing.

Conclusions: These results that the elevated Apo E ε4 frequency in the PDD groups, in which the overall brain neuritic plaque burden was low, indicates that apoE ε4 might contribute to neurodegeneration through mechanisms unrelated to amyloid processing.

References: •Kang HU, Park MY. Apolipoprotein E ε4 allele frequency in Korean patients with vascular dementia. J of the Korean Dementia Ass. 2002; 1: 34-8.

•Debby Tsuang, James B. Leverenz, Oscar L. Lopez, Ronald L. Hamilton, et al. APOE ε4 increases risk for dementia in pure synucleinopathies. JAMA Neurol. 2013; 70(2): 223–228.

•Strittmatter WJ, Saunders AM, Alberts MJ, et al. Apolipoprotein E: highavidity binding to B-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer’s disaese. Proc Natl Acad Sci USA 1993; 90: 1977-81.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/apolipoprotein-e-%ce%b54-allele-frequency-in-korean-patients-with-parkinsons-disease-dementia/