Objective: The aim is to evaluate and compare the apathy profile in PwHD and PwPD, using the same clinical criteria to assess the severity of apathy, cognitive and depressive symptoms.

Background: Apathy is frequent, disabling and difficult-to-treat symptom of neurodegenerative disorders[Mário Sousa, 2018]. In PwHD and PwPD prevalence of apathy is highly variable ranging from 7–76%[Duijn E.,2014].

Method: The registry of patients with neurodegenerative diseases has been maintained in the Siberian State Medical University more than 10 years(833 patients). The individual registration card is filled out for each patient: demographic data, motor and NMS of the disease, validated scales and questionnaires on physical activity(MDS-UPDRS, UHDRS), cognitive functions(MoCA-test), anxiety, depressive symptoms(HADS; BDI-II) and apathy(apathy scale). Patients with dementia or severe depression were excluded from research.

Results: The study included 265 individuals: 250 PwPD, 15 PwHD (equivalent by gender, age, education). Apathy was presented in 36.3%PwPD and 53.3%PwHD. In both groups, apathy was associated with the severity of motor manifestations according to MDS-UPDRS(part III)/UHDRS. Moreover, a more expressed correlation of apathy was observed in PwPD with more severe depression(r=0.568;p<0.0001), anxiety(r=0.524;p<0.0001), sleepiness(r=0.364;p=0.001); negatively apathy correlation was observed with disease duration(-0.445;p<0.0001) and LEDD(-0.395;p<0.0001). In PwHD apathy was associated with disease duration(0.445;p<0.0001) and cognitive impairment(0.482;p<0.0001).

Conclusion: Similar apathy prevalence was found in PwPD and PwHD with different clinical correlations and involvement of different areas of apathy, which requires further research for developing targeted therapy.

« Back to MDS Virtual Congress 2020

MDS Abstracts - https://www.mdsabstracts.org/abstract/apathy-as-a-non-motor-symptomnms-in-patients-with-parkinsons-diseasepwpd-and-patients-with-huntingtons-diseasepwhd-in-tomsk-russia/