Objective: It is well known that the oxidative stress might be associated with the pathomechanisms of Parkinson’s disease (PD). In this study, we assessed serum oxidized, non-mercaptoalbumin (NA) as a biomarker for PD.

Background: PD is the second most frequent neurodegenerative disorder with increased age-dependent incidence. Although oxidative stress derived from mitochondrial dysfunction has been suggested to be associated with PD pathogenesis, biomarkers have been rarely detected. Albumin is widely distributed the inside and outside of blood vessels in human body, and further glycosylation and oxidation of albumin reflects the state of whole body. The redox ratio of serum NA and reduced, mercaptoalbumin (MA) is known the association with oxidative stress. Hence, we examined whether the redox ratio of serum MA and NA (% MA = MA / (MA + NA) *100) might be a useful marker for the risk or progression of PD.

Methods: We enrolled 71 patients with PD followed at outpatient department of Juntendo University Hospital, Tokyo, Japan. Six patients with renal insufficiency (serum creatinine >1.0 mg/dl) or glucose intolerance (HbA1c ≧6.5%) were excluded. 65 PD (35 females, mean [SE]; age 64.0 [0.99] years, Hoehn & Yahr 2.15 [0.13], disease duration 6.66 [0.79] years, Mini-Mental state examination (MMSE) 28.9 [0.16]) patients and 30 healthy controls (18 females, mean [SE]; age 64.0 [1.97]) were examined by the redox ratio of serum MA and NA (%MA = MA/(MA+NA) *100). We analyzed these data using Student t-test’s or ANOVA.

Results: %MA was not different between PD patients and control group. Specifically, PD patients with higher age (≧75 years), higher Hoehn & Yahr (4 or 5), longer disease duration (≧10 years), lower MMSE score (26 points≧) and the control group compared with each other (p>0.05). However, when only PD patients were analyzed, PD with higher Hoehn & Yahr (4 or 5) and lower MMSE score (26 points≧) had lower %MA.

Conclusions: No statistically higher %MA in PD than in control may be caused by a small number of subjects. It should be further clarified with more patients whether advanced PD might be associated with increased oxidative stress.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/analysis-of-serum-non-mercaptoalbumin-in-patients-with-parkinsons-disease/