Objective: To evaluate an association between impulse control disorders (ICDs) and dopamine agonists (DA) therapy in Japanese patients with Parkinson’s disease (PD).

Background: ICDs such as compulsive gambling, shopping, eating, hypersexuality, and punding occasionally occur in PD patients. It has been reported that male, juvenile onset and young people were potential risk factors of ICDs. In addition, ICDs is considered to be associated with high dose of DAs. However the dosage of DAs in Japan is relatively lower than that in U.S. or European countries.

Methods: We investigated prevalence and severity of ICDs using questionnaire for impulsive-compulsive disorders in Parkinson’s disease (QUIP) and usage of DAs in Japanese PD patients. 362 consecutive patients who visited Ehime university hospital in 2015 were screened, and 211 (95 males, 116 females) out of 362 patients were eligible for this study.

Results: The mean dose of levodopa was 380.8 mg / day, and the mean of total levodopa equivalent dose was 543.2 mg / day. The mean of the QUIP score was 0.379, and the score of 44 patients showed no less than one point which was recognized as ICDs. The prevalence of ICDs in male patients was significantly higher than that in female patients. The prevalence of ICDs in non-ergot DA treated patients showed no difference from that in ergot DA treated patients. However the dosage of pramipexole and ropinirole correlated positively with the QUIP score. The dosage of ergot DA and rotigotine showed no correlation with the QUIP score.

Conclusions: In Japanese PD patients, the prevalence of ICDs was associated with the usage of pramipexole and ropinirole, and the severity of ICDs correlated with the dosage of pramipexole and ropinirole.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/an-association-between-impulse-control-disorders-and-dopamine-agonists-in-japanese-patients-with-parkinsons-disease/