Objective: To correlate activities of daily living (ADL) and quality of life (QoL) in advanced Parkinson’s disease (APD) patients with ongoing or planned device-aided treatment (DAT) and to identify characteristics that may predict ADL and QoL response on DATs.

Background: ADL influences the QoL in patients with APD. However, it is unknown how disease characteristics (eg, motor fluctuation/PD duration) affect ADL and patient QoL.

Methods: This was a post hoc analysis of OBSERVE-PD, a global, multicenter, cross-sectional, observational study conducted at 128 movement disorder centers in 18 countries. ADL was assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS) Part II; QoL was assessed using Parkinson’s disease 8-item questionnaire (PDQ 8). DATs included deep brain stimulation, levodopa-carbidopa intestinal gel infusion, and continuous apomorphine subcutaneous infusion. The correlation between ADL and QoL was assessed in patients with APD who were eligible for DAT (planned and ongoing) using Pearson correlation coefficients.

Results: This analysis included 384 patients with ongoing DAT and 164 patients who planned to initiate DAT. Despite a longer disease duration and higher age (Table 1), patients receiving DAT generally had better scores for ADL and QoL than did patients who planned to initiate DAT. (Table 2) The group of patients with >4 years motor fluctuation and >10 years since PD diagnosis who were receiving DAT also tended to have slightly better scores for ADL and QoL compared with patients who were planning to initiate DAT. ADL and PDQ-8 scores were strongly correlated for patients with ongoing DAT (r = 0.54722; P<.0001) and planned DAT (r = 0.55487; P<.0001). [table1] [table2]

Conclusions: Patients with planned DAT generally had worse ADL and QoL than did patients with ongoing DAT, suggesting that DAT improves patient-reported outcomes in the long-term. ADL and QoL were strongly correlated in patients who had ongoing and planned DAT. These data demonstrate the importance of assessing ADL and QoL in patients with advanced PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/activities-of-daily-living-and-quality-of-life-in-patients-with-advanced-parkinsons-disease-who-are-treated-with-or-planning-to-use-device-aided-treatments/