Objective: Introduction: Cinnamomum verum is a very common traditional Indian Spice known as Darchini. It is obtained from the inner bark of several species of the genus Cinnamomum; used in both sweet and savory foods. It is the best spice available in terms of its nutrition and health and contains unique healthy and healing property due to the presence of active components. Orally administrated C.verum extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer’s Disease Animal Models has been done by Anat Frydman et al., in 2011 but there are only a few studies done on its effect on stress and anxiety. This leads to a hypothesis to search for Cinnamon that may cause improvement in locomotor behavior or anxiety suppression.

Background: The present study was carried out to evaluate the anti-anxiety, locomotor activity and emotional behavior of C.verum, so as to validate its use as anti-anxiety, an anti-stressor drug in the Unani system of medicine.

Methods: Material and Methods: Female Wistar rats of weighing 150-180 gm were divided into 4 groups of 6 animals each. The animals in Group I were Control and Group II had acute noise stress (of 100dB intensity) for 30days, whereas animals in Group III gave aqueous extract of C.verum (200 mg/Kg/body weight) were dissolved in saline (1 ml) and administrated for 30 days orally and IV were given aqueous extract of C.verum along with acute stress for 30days, respectively orally, once a day (duration of treatment has been stated with respective tests). A battery of tests viz. Open Field Behaviour Test and Elevated Plus Maze Test, were used to study the anti-anxiety, anti-stressor effect of C. verum. Statistical significance between the different groups was determined by one-way analysis of variance (ANOVA). If the groups showed a significant difference, Tukey’s multiple comparison tests were done. The significance level was fixed at P< 0.05.

Results: In this study clearly infer that Cinnamom could alter the behavior pattern in rodents. In the open field, the Cinnamom treated animal significant decrease in its locomotor activity. However, in the present study, aggressive or escape behavior, such as jumping, digging, climbing, and gnawing was not exhibited by any of the animals during the open field test. The cinnamom treated group showed a marked decrease in immobilization and fecal bolus with the decrease in ambulation of the central and peripheral square when compared to the respective control groups indicated the fearlessness. Moreover, the cinnamom treated animals showed the marked decrease in rearing and grooming from the control as well as from the stress control animals.

Conclusions: C.verum may cause an improvement on anxiety, locomotor activity and emotionality behaviour in Wistar Albino rats. The improvement may be due to the metabolite of C. verum and the improvement can also be possible by the antioxidants generated during cinnamom metabolism.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/a-preliminary-study-of-cinnamomum-verum-on-anxiety-locomotor-activity-and-emotionality-behaviour-in-wistar-albino-rats/