Objective: Drug induced parkinsonism (DIP), caused by various group of drugs, is second most common etiology of parkinsonism after Idiopathic Parkinson’s disease (IPD). No major studies are done in India till date as far our knowledgeTo Study clinical profile of drug induced parkinsonism (DIP) and to differentiate it from idiopathic Parkinson’s disease (IPD).

Background: The incidence of DIP in the general population is reported to be 20 % of patients with parkinsonism, less than half of PD cases ]. The incidence of DIP among patients taking neuroleptics varies from 15 to 40%, depending upon the type and dose of neurolepticsDrug-induced movement disorders include drug-induced parkinsonism (DIP), tardive dyskinesia (TD), tardive dystonia, akathisia, myoclonus, and tremor. The true prevalence of drug induced parkinsonism is not known as the condition is often under-recognised and epidemiological studies tend to include all types of parkinsonism or drug induced movement disorders, rather than drug induced parkinsonism alone.

Methods: In our cross sectional study, we studied the clinical and epidemiological characteristics 30 patients with DIP, and compared the clinical and epidemiological characteristics with those of 30 patients with IPD.

Results: Antipsychotic drugs were most common drugs causing DIP. Mean duration of parkinsonism after drug exposure was 5.77±8.41 months. The DIP group differed from the IPD group: symmetrical rigidity/bradykinesia in 25/30 DIP patients, and in 7/30 0f IPD patients (p < 0.000). Action tremor was present in 14/30 DIP patients and about 8/30 IPD patients (p < 0.000). Mean H & Y stage for DIP patients was 2.24±0.84 and that of for IPD patients was 1.55±0.577, which was statistically significant (P value=0.012). Mean Shwab and England ADL Scale for DIP patients was 72±13.24 % and that of for IPD patients was 79.67±9.27, which was statistically significant (P value=0.03). In DIP abnormal involuntary movements are present in 8/30 DIP patients and absent in IPD. There was no statistically significant difference for age of onset and gender distribution among two groups.

Conclusions: Symmetric parkinsonism is more common in DIP. Postural tremor most common tremor in DIP. Presence of abnormal involuntary movements temporally related to drug intake help to differentiate from DIP and IPD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/a-comparative-study-of-clinical-profile-of-patients-of-drug-induced-parkinsonism-with-idiopathic-parkinsons-disease/