Objective: To design a computational modeling to develop a new diagnostic tool for effective neuro-medical-diagnostics for end users, to investigate and evaluate the potential benefits of multivariate and other techniques, to study the effectiveness of microelectrode-recording(MER) in determining final tract for placing DBS electrode during bilateral STN-DBS.

Background: DBS is one effective method to reduce motor symptoms in subjects with Parkinson’s disease (PD). However, objective methods for quantifying its efficacy are lacking. Therefore, we present a fusion study for determining the effects of DBS in PD using MER to measure MER signal-parameters(amplitude, frequency, pulse-width,etc).

Methods: The channel with maximum recording and the earliest recording were recorded on both sides. Intraoperative test stimulation was performed in all channels from the level at the onset of MER recording. Stimulation was done at 1mv, 3mv to assess the improvement in bradykinesia, rigidity and tremor. Appearance of dyskinesias was considered to be associated with accurate targeting. Side effects were assessed at 5mv and 7mv to ensure that the final channel chosen had maximum improvement with least side effects. Correlation was assessed between the aspects of MER and the final channel chosen in 46subjects(92sides).

Results: In 28 subjects, the final tract did not correspond either to the tract with highest MER signal recording or the maximum width of MER: 13 subjects had central tract, 8 had anterior,7 had medial tract as final tract, Mean-length of MER recording in these channels was 2.3+ 1.8 mm.

Conclusions: It may be concluded that, the MER signal measurements are potentially useful for quantifying the effects of DBS on the neuromuscular function of PD subjects. These measurements in combination with the latent variate factorial method, a mathematical analysis which is a principal component (PC) based tracking method can be used to quantify the effects of DBS objectively, cost-effectively and non-invasively and in further studies, the presented approach could be tested in helping the adjustment of DBS settings. In addition, the sensitivity of the presented method to different types of PD should be estimated more carefully in further clinical and/or diagnostic studies.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/objective-methods-for-quantifying-the-deep-brain-stimulation-dbs-efficacy-in-subthalamic-nuclei-stn-neurons-with-microelectrode-recording-mer-technology/