Objective: To investigate frontal N30 in Parkinson’s disease (PD), and to examine the correlation between amplitude of frontal N30 and the degree of motor deficits.

Background: Employing somatosensory evoked potentials (SEPs) is useful for evaluation of the central somatosensory pathway, even in patients with normal brain MRI findings. SEP abnormalities can reflect the dysfunction of brain areas functionally connected to the sensorimotor cortex.

Methods: 17 PD patients and 18 healthy volunteers were participated. We compared Frontal N30 between the PD patients and the healthy volunteers. We studied the correlation between amplitude of frontal N30 and Unified Parkinson’s disease Rating Scale (UPDRS) motor score of the more-severely affected side.

Results: The mean latency of N30 between patients and healthy volunteers was not significantly different (p = 0.981), but the mean amplitude was significantly lower in PD patients (p < 0.025). Significantly negative correlation was seen between the amplitude of N30 and UPDRS motor score (r = -0.715, p = 0.013).

Conclusions: Our study suggests that the frontal N30 status indicates the severity of motor function of PD. It can be a useful biomarker reflecting dopaminergic deficits, and an objective measurement for monitoring clinical severity of PD.

This abstract was presented as a poster at XXI World Congress on Parkinson’s disease and Related Disorders, 6-9 December 2015.

« Back to 2016 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/the-correlation-between-n30-sep-and-motor-function-in-parkinsons-disease/