Objective: We aimed to compare the severity of depression and anxiety in Parkinson’s disease (PD) patients with pain and without pain, and demonstrate the relationship between pain and depression.

Background: The association between pain and mood disorder such as depression and anxiety has been rarely described in PD.

Methods: We prospectively enrolled 162 patients with PD. We investigated demographic characteristics, Parkinsonian motor symptoms, pain, depression, anxiety and quality of life (QOL). We used the non-motor symptom scale (NMSS) to evaluate pain in all patients. Depression and anxiety was assessed by Beck depression inventory(BDI) and Beck anxiety inventory(BAI) and quality of life by The 39-item Parkinson’s disease Questionnaire(PDQ-39). We compare aforementioned scores between PD patient with and without pain. In the group of patients with pain, we analyzed the correlation between pain and PD related metrics.

Results: 27 (16.7%) of 162 patients suffered from pain. The scores of BDI, BAI and PDQ-39 in patients with pain were higher than those in patients without pain. Depression, anxiety and QOL were significantly associated with pain in the group of patients with pain.

Conclusions: A significant relationship of pain with depression, anxiety and QOL. Mood disorders and pain are common conditions with great attribution for the patient’s QOL and the nature of this relationship and their combined management should be addressed in future studies.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/association-of-mood-and-affective-disorders-with-pain-in-parkinsons-disease/