Session Information
Date: Monday, June 20, 2016
Session Title: Parkinson's disease: Non-motor symptoms
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To investigate whether rapid eye movement sleep behavior disorder (RBD) is associated with depression or anxiety in patients with Parkinson’s disease (PD).
Background: RBD is the one of non-motor symptoms of PD and recently considered as the noticeable feature in the prodromal phase. On the other hand, depression and anxiety are also non-motor symptoms of PD and may emerge before the clinical manifestation of parkinsonism. Although these symptoms sometimes coexist in PD patients, the prevalence or the degree of depression and anxiety in PD patients with or without RBD is poorly understood.
Methods: In 48 PD patients with RBD (30 males) and 40 PD patients without RBD (23 males), non-motor symptoms including depression and anxiety, were evaluated by the Japanese version of Hospital Anxiety and Depression Scale (HADS) for quantifying those symptoms (cut-off point for depression or depression = 8/21). Motor symptoms were evaluated by the modified Hoehn and Yahr (mHY) scale. Diagnosis of RBD was dependent on the results of the Japanese version of the RBD Screening Questionnaire or RBD symptoms confirmed by polysomnography.
Results: The score of both depression (7.8 ± 0.6 vs. 6.0 ± 0.5, P = 0.02) and anxiety (6.8 ± 0.4 vs. 4.4 ± 0.5, P = 0.001) of all patients in each group were statistically higher in PD patients with RBD than in PD patients without RBD. Evaluation of the prevalence of both depression (52.1% vs. 35.0%) and anxiety (39.6% vs. 22.5%) showed trends for a higher frequency in PD patients with RBD than in PD patients without RBD, although not statistically significant (P = 0.08, 0.07, respectively). There was no significant difference of the mHY scale between these two groups. Data of the score are presented as the mean ± S.E..
Conclusions: The presence of RBD could be the risk of depression and anxiety in PD patients. Because the score of both depression and anxiety scale showed higher in PD patients with RBD than in PD patient without RBD, symptoms of depression and anxiety should be taken into consideration in those patients, even if they do not meet the diagnostic criteria for depression or anxiety.
To cite this abstract in AMA style:
Y. Saitoh, Y. Mukai, T. Sakamoto, M. Murata. Depression and anxiety in Parkinson’s disease with rapid eye movement sleep behavior disorder [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/depression-and-anxiety-in-parkinsons-disease-with-rapid-eye-movement-sleep-behavior-disorder/. Accessed November 22, 2024.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/depression-and-anxiety-in-parkinsons-disease-with-rapid-eye-movement-sleep-behavior-disorder/