Objective: We aimed to analyse the mortality and prevalence of Movement Disorders and Malignant Neoplasms from 1999-2020 in the United States to compare disparities among various sociodemographic groups.

Background: Movement Disorders (MD) are a group of neurological disorders that lead to losing control over the patient’s movements. These disorders manifest as involuntary movements or difficulty in conducting voluntary movements. Malignant Neoplasms (MN) are a group of pathologies characterized by uncontrolled growth and spread of cancerous cells.

Method: Death Certificates from CDC Wonder (Centres for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) database were examined from 1999 to 2020 for MD (ICD-10 Codes: G20-G25) and MN (ICD-10 Codes: C00-C97). Age-adjusted mortality rates (AAMRs) per 1,000,000 people and annual percent change (APC) were stratified by age groups, sex, race, census region, urbanization, and state. The Joinpoint Regression Program was utilized to calculate Annual Percent Change (APC) trends for MD and MN-related AAMRs.

Results: The AAMRs for MD & MN declined from 1999 to 2015 (APC: -1.55 CI: -1.80 to -1.30) with a recent rise from 7.30 in 2015 to 9.85 in 2020 (APC: 5.69 CI: 4.29 to 7.11). 85+ years-olds had a significantly higher crude rate throughout the study. Males had greater AAMRs than females but the trends remained similar (Overall AAMR, Males: 14.47 CI: 14.33 to 14.61; Females: 4.42 CI: 4.36 to 4.48). White Americans had the highest incidence of MD and MN-related mortality (Overall AAMR: 8.82 CI: 8.75 to 8.9). In terms of urbanization, AAMRs remained higher in rural populations (Overall AAMR: 9.32 CI: 9.1 to 9.51) than urban populations (Overall AAMR: 7.43 CI: 7.31 to 7.55). Deaths were concentrated in Western (Overall AAMR:) and Midwestern America (Overall AAMR, West: 9.21 CI: 9.06 to 9.37; Midwest: 9.5 CI: 9.35 to 9.65). Concerning states, Minnesota, Nebraska, Colorado, and Montana were in the top 90th percentile.

Conclusion: There has been a steep rise in MD and MN related deaths in the US within all the sociodemographic variables. In this study, we highlight the need to study the cause of this rapid rise. Males and White Americans were identified as the highest at-risk groups. Western and Midwestern US, particularly rural populations, were recognized as hotspots. This data can be used to formulate targeted policies for these populations.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/trend-analysis-of-movement-disorders-malignant-neoplasms-and-mortality-from-1999-2020/