Category: Parkinson's Disease: Cognitive functions
Objective: The aim of the present study was to know the influence of the level of education (LoE) on the change in cognitive function (CF) in patients with Parkinson´s disease (PD).
Background: LoE is widely used as an indicator of cognitive reserve. That higher LoE is associated with lower risk of dementia supports this idea. However, prospective studies suggest that this association is mostly attributable to the association of education with level of CF rather than rate of cognitive change.
Method: PD patients from the Spanish cohort COPPADIS1 with a disease duration from symptoms onset ≤ 5 years, who were recruited from January/2016 to November/2017 (baseline visit; V0) and evaluated at 2 (V2), 4 (V4) and 5 (V5) years of follow-up were included. Regarding LoE, patients were classified as with primary, secondary and university studies. CF was assessed using the Parkinson´s Disease Cognitive Rating Scale (PD-CRS). According to the PD-CRS total score, patients were classified as with normal cognition (PD-NC; PD-CRS total score > 80), mild cognitive impairment (PD-MCI; PD-CRS total score < 81 and > 64), and dementia (PDD; PD-CRS total score < 65). General linear model (GLM) repeated measure was used to test for changes in the CF and the Bonferroni method as a post-hoc test after ANOVA.
Results: Three hundred and ninety-nine PD patients (61.9 ± 8.9 years old; 58.4% males) with a mean disease duration at baseline of 2.7 ± 1.5 years were included. LoE was: 40.4% (N=161) primary; 32.5% (N=130) secondary; 27.8% (N=108) university. At baseline, CF (PD-CRS total score) and cognitive status was associated with LoE (p<0.0001) (Figure 1A and 1B). From V0 to V5, significant differences were observed in global and fronto-subcortical (p<0.0001 in all visits) between LoE groups but not in posterior-cortical (p>0.05 in all visits) CF (Figure 2). A significant decrease was observed in the PD-CRS total score in PD patients with primary studies (from 84.9 ± 13.5 at V0 to 79.05 ± 21.4 at V5; p=0.001) but not in those patients with secondary (p=0.068) and university (p=0.061) studies. LoE was associated with the change from V0 to V5 in the PD-CRS total score and fronto-subcortical score (p<0.0001) after adjustment to age, gender, disease duration and levodopa equivalent daily dose at each visit.
Conclusion: Change in cognitive function in Parkinson´s disease is influenced by the level of education.
Figure 1.
Figure 2.
References: 1. Santos García D, Jesús S, Aguilar M, et al.; COPPADIS Study Group. COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015): an ongoing global Parkinson’s disease project about disease progression with more than 1000 subjects included. Results from the baseline evaluation. Eur J Neurol 2019;26:1399-1407.
To cite this abstract in AMA style:
D. Santos García, T. de Deus, C. Cores, M. íñiguez, L. Samaniego, J. Paz González, S. Jesús, M. Cosgaya, J. García Caldentey, N. Caballol, I. Legarda, I. Hernández Vara, I. Cabo, L. López Manzanares, I. González Aramburu, M. Avila, V. Gómez Mayordomo, V. Nogueira, J. Dotor, C. Borrué, B. Solano, M. álvarez Sauco, L. Vela, S. Escalante, E. Cubo, Z. Mendoza, J. Martínez Castrillo, P. Sánchez Alonso, G. Alonso Losada, N. López Ariztegui, I. Gastón, J. Kulisevsky, M. Seijo, C. Valero, R. Alonso Redondo, T. Buongiorno, C. Ordás, P. Martínez Martín, P. Mir, S. Coppadis. Influence of the Level of Education on the Change in Cognitive Function in Parkinson´s Disease. A 5-year Follow-up Study. [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/influence-of-the-level-of-education-on-the-change-in-cognitive-function-in-parkinsons-disease-a-5-year-follow-up-study/. Accessed November 23, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/influence-of-the-level-of-education-on-the-change-in-cognitive-function-in-parkinsons-disease-a-5-year-follow-up-study/