Objective:

To identify which social and clinical factors are related to disparities between the distribution of DBS in Mexican PD population

Background: Deep Brain stimulation (DBS) has become the mainstream surgical procedure for patients with advanced Parkinson’s Disease (PD) [2]; it is technique which involves applying high frequency electrical stimulation to the subthalamic nucleus or internal globus pallidus has been shown to improve quality of life and motor function. [3] Some prevalence studies indicate that PD affects men more than women and others have shown that DBS undergoing is higher in men than in women. [2,4]

Method:

A retrospective cross-sectional study was carried out. People with PD who underwent DBS between 2021 and 2023 we’re included. Data records included gender, employment, socioeconomic status, ace, disease duration and motor and non-motor assessments at the time of surgery. U Mann-Whitney was used to compare: MDS-UPDRS2, Non-motor symptoms scale [NMS] , 39-item Parkinson’s Disease Questionnaire index [PDQi] and  King’s Parkinson’s Disease Pain Scale [KPSS].

Results:

27 Mexican PwP (79.4% males; 53.62  ± 10.61years old) with significant difference in women in UPDRS2, NMS TOTAL, KPSS TOTAL and PDQ index (p= .025, .009, .039, .005, .005 respectively). Moreover, with differences in socioeconomic status (low and high income) and employment (p=.027 and .001 respectively). Other records were not significant.

Conclusion:

While there may be differences in the prevalence and symptoms between men and women, the underlying mechanisms of DBS and its effects on the brain are not believed to vary significantly based on gender nevertheless women may face unique considerations and challenges related to DBS treatment.

References: 1. Stefanie T. , Lena S., et.al. Gender gap in deep brain stimulation for Parkinson’s disease. NPJ . 2022.
2. Gun-Marie H., Takeshi N., et.al. Gender distribution of patients with Parkinson’s disease treated with subthalamic deep brain stimulation; a review of the 2000e2009 literature. ELSEVIER. 2010
3. Danielle S. , Daniel G., et.al. Gender Disparities in Deep Brain Stimulation for Parkinson’s Disease. Neuromodulation: Technology at the Neural Interface. 2019
4. Nachiket D., River G. , Rushna A. Evaluation of DBS Timeline in Movement Disorders: A Comparison Between Genders. ELSEVIER. 2022

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MDS Abstracts - https://www.mdsabstracts.org/abstract/differences-of-social-and-clinical-factors-related-with-distribution-of-dbs-in-mexican-pd-population/