Objective: In the last decade, attention has been focused on the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system, insulin in the brain is involved in neuronal survival, plasticity, oxidative stress, and neuroinflammation.

Background: Parkinson’s disease and diabetes mellitus are aging-related diseases that are growing into epidemics around the world.

Method: Clinical study was conducted from September 2022 to January 2023 .The group of examined patients consisted of 30 people who met the criteria and symptoms of The examined were divided into two groups with Parkinson’s disease without diabetes mellitus and with the presence of diabetes mellitus.

Patients were examined in the 1st polyclinic of the Tashkent Medical Academy at the Department of Neurology, a clinical and neurological study was carried out with the collection of biochemical analysis,also patients were examined by computed tomography (CT) or MRI. A survey was conducted on the quality of life and the state of cognitive functions using a scale (MDS-UPDRS 2007)

Results: The groups were formed according to the results of the clinical-neurological history and biochemical markers. These 2 studied groups were identified: the first group of 21 patients 70%, p≤0,001 with Parkinson’s disease without DM , and the second group of 9 patients  30% p≤0,01  PD with diabetes mellitus. According to the results of the survey, patients with DM had 15% p≤0,05   higher rates of higher cortical dysfunctions. Based on the data: attention, memory, executive functions and language were less affected in the first group of patients without diabetes mellitus. The correlation is r=0.65, p≤0,05

Conclusion: This small study demonstrated the impact of type DM on the clinically negative progression of higher cortical functions in patients with Parkinson’s disease. There is currently no curative treatment available for Parkinson’s disease, but the role of insulin and antidiabetic drugs in the neuroprotection of higher cortical functions opens a new role in both diabetic and non-diabetic Parkinson’s patients. This result is a more clinical assumption, but to confirm the relationship, need to process a more detailed study in a larger group of patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/%d1%81linical-neurological-features-of-diabetic-and-non-diabetic-patients-with-parkinsons-disease/