Category: Parkinson's Disease: Neurophysiology
Objective: Our study aimed to establish the objective physiological indicators assessed by polysomnography(PSG) that are associated with dyskinesia in PD patients.Our study aimed to establish the objective physiological indicators assessed by polysomnography(PSG) that are associated with dyskinesia in PD patients.
Background: Levodopa is the most effective drug for symptomatic treatment for Parkinson’s disease (PD), but levodopa-induced dyskinesia after long-term treatment is difficult for doctors, and adversely affects quality of life of patients. However, few studies have focused on the relationship between dyskinesia and sleep and electroencephalography.
Method: We enrolled 122 patients with PD, divided into 2 groups: PD with dyskinesia (DYS, n=27) and PD without dyskinesia group (non-DYS, n=95). The demographics and clinical characteristics and sleep assessment in the two groups were collected. More importantly, over-night 6-channel PSG parameters were compared in the two groups.
Results: Compared with the non-DYS group, the DYS group tended to have a significantly higher ratio of non-rapid eye movement sleep (NREM). Disease duration, levodopa equivalent daily dose, and the NREM ratio were positively correlated with the occurrence of dyskinesia. After adjusting for gender, disease duration, levodopa equivalent daily dose, sleep efficiency, and other covariants, the ratio of NREM sleep was still associated with dyskinesia. The DYS group had lower frontal slow-wave electroencephalo-graph(EEG) spectral density during NREM throughout the night (P=0.038). Low-frequency (0.5–2 Hz) slow wave activity(SWA) reduction in the frontal area was still associated with dyskinesia in logistic regression after adjusting for gender, disease duration, levodopa equivalent daily dose, age, and other confounding factors (P=0.003).
Conclusion: PD patients with dyskinesia have substantial sleep structure variation. Higher NREM ratio is an independent risk factor of dyskinesia. The decrease of synaptic downscaling of the motor cortex during NREM sleep may participate in the occurrence of dyskinesia in PD. Low-frequency (0.5–2 Hz) SWA reduction in the frontal area could be a new electrophysiological marker of dyskinesia in PD.
To cite this abstract in AMA style:
CJ. Mao, YM. Wang, F. Wang, CK. Zhong, S. Zhuang, XY. Cheng, JY. Liu, CF. Liu. Delta(0.5-2Hz) Spectral Power reduction in the frontal region in NREM Sleep are Associated with dyskinesia in Parkinson’s Disease [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/delta0-5-2hz-spectral-power-reduction-in-the-frontal-region-in-nrem-sleep-are-associated-with-dyskinesia-in-parkinsons-disease/. Accessed November 23, 2024.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/delta0-5-2hz-spectral-power-reduction-in-the-frontal-region-in-nrem-sleep-are-associated-with-dyskinesia-in-parkinsons-disease/