Category: Parkinson's Disease: Pathophysiology
Objective: Ongoing research of electrophysiological characteristics in Parkinson`s do not take aging brain into account. So, we aim is to show impact of aging on beta-oscillations and oscillatory patterns in rest/movement at cortical, sub-cortical levels.
Background: Initially, EEG variations were studied as a marker for pathological aging. It is currently assumed that in healthy aging analogous/related variations occur. Aging is linked to the flattening of a ramp(angle-slope) in the power-spectrum plus an rise in high-frequency-power(HFP). The lack of tests for individuals suffering as of PD results in higher needs for care and earlier housing in tertiary health care-research centers.
Method: A high-density EEG data in rest and a simple motor task. We acquire electrophysiological data intra and post op merging micro-electrode recordings(MER), local field potentials (LFP) with percept-medtronic. Spectral-power, frequency-of-alpha behavioral-activity decreases also differing theta/delta power-activity progresses as a function-of-age. In regard to PD, variations in beta-band through aging are of specific significance, as PD is differentiated with extreme beta-synchronization in the cortico-basal-ganglia net-work.
Results: Beta activity is thought to be connected to disease-gravity, motor-impairment. But usually aging-analyses show overall growth in power of beta-band by age, certain point to a non-linear correlation, rise in power-up to late-middle age plus a reduction afterward. Changes in beta unrelated to cerebral-effects of aging. A decrease in beta prior to activity induction is reflected in basal-ganglia, motor-cortex, in STN. This decrease seems more evident in adults. Recent information on contact amongst ageing, Parkinson`s over EEG patterns of brain is scarce, data is scanty. We showed that older Parkinson`s have a lesser high-level frequency-power in STN. Results show calendar-age is not just linked by a decrease in HFP though a diminution in STNbeta(Figure1).
Conclusion: The causes of disease-process also aging on electro-neuro-physiological activity, especially over beta-movement/activity, involve a biological-interaction. Present research of electro-physiological-characteristics within Parkinson`s ought to hence not just linked to disease-process within substantia-nigra(SN) pars-compacta, yet aging-brain into account. So, this may result in new insights that ultimately suggest chances to alter the clinical-experimental evolution of disease.
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To cite this abstract in AMA style:
V. Rama Raju. Aging brain in Parkinson`s: A study through biomarkers [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/aging-brain-in-parkinsons-a-study-through-biomarkers/. Accessed September 7, 2024.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/aging-brain-in-parkinsons-a-study-through-biomarkers/