Category: Parkinson’s Disease: Clinical Trials
Objective: The study aim was to investigate the effect of structured training concerning motor fluctuations on the agreement between observer and HD ratings and daily motor state times.
Background: Recent studies showed only fair agreement between observer and patients motor state assessments on the Parkinson’s disease (PD) Home Diary (HD) [1,2]. This could possibly be explained by the patients’ insufficient knowledge about motor fluctuations.
Method: Participants from a previous validation study of the HD were invited back for a study extension [2]. This interventional study consisted of a screening visit including a structured training concerning motor fluctuations and one day of motor ratings on-site during which observer and patient simultaneously and independently evaluated the patients motor state half-hourly.
Results: Observer and 20 patients completed 316 pairs of motor state assessments. The overall agreement was 68% before training and 76% after training (P = .093) and Cohen’s κ increased from .438 to .559 (P = .320). There was no significant improvement in the correlation/reliability of HD-documented daily motor state time when compared with observer ratings [figure 1]. Moreover, before training the agreement in observed “on with dyskinesias” was 58% and after training it was 80% (P = .074) [figure 2].
Conclusion: Our structured patient training in motor fluctuations did not significantly improve the agreement between observer and HD or the reliability of daily times spent in the different motor states as an aggregate measure of the HD in this PD patient group. However, there are indications on an improvement in the participants ability to detect dyskinesias.
Previous presentation: CTNR – Winter school 23-01-27.
References: [1] Löhle M, Bremer A, Gandor F, Timpka J, Odin P, Ebersbach G, et al. Validation of the PD home diary for assessment of motor fluctuations in advanced Parkinson’s disease. npj Parkinson’s Disease. 2022;8(1):69.
[2] Timpka J LM, Bremer A, Christiansson S, Gandor F, Ebersbach G, et al.. Objective observer versus patient motor state assessments using the PD Home Diary in advanced Parkinson’s disease. Front Neurol. 2022.
To cite this abstract in AMA style:
C. Janz, J. Timpka, M. Löhle, A. Bremer, F. Gandor, G. Ebersbach, A. Storch, P. Odin. Agreement between Parkinson disease Home Diary and observer assessments before and after structured patient training [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/agreement-between-parkinson-disease-home-diary-and-observer-assessments-before-and-after-structured-patient-training/. Accessed September 7, 2024.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/agreement-between-parkinson-disease-home-diary-and-observer-assessments-before-and-after-structured-patient-training/