Objective: To explore the impact of the cerebral ventricular dimension on treatment response in Parkinson’s disease (PD).

Background: In addition to PD, the second most common neurodegenerative disorder, an enlarged ventricle, such as normal pressure hydrocephalus, is another leading cause of gait trouble and falling injury in the senile population. Being unsure of presence or absence of relationship between both conditions, we may conceive a detrimental effect of a larger ventricle on motor manifestations in PD.

Method: The current registry-based retrospective cohort study enrolled 101 drug naïve and de novo patients with PD, who were stratified by the Unified Parkinson’s Disease Rating Scale (UPDRS) improvement in 1 year, such that a group of the Best (n = 31; UPDRS III, > 10), the Moderate (n = 43; UPDRS III, 5-10), and the Modest (n = 27; UPDRS III, < 5). Parameters of the ventricular morphometrics included Evan’s index (EI), frontal-occipital horn ratio (FOHR), callosal angle (CA), callosal height (CH), and temporal horn width (THW).

Results: The Modest group demonstrated significantly a larger ventricular dimensions including EI, CA and FOHR. Better improvements of the UPDRS III scores were noted in the patients with smaller ventricular dimensions (EI, correlation coefficient (r), 0.637; FOHR, r, 0.405; CA, r, -0.437; CH, r, 0.366; p < 0.001 apiece). Furthermore, every ventricular parameter demonstrated to predict effectively the better treatment response in PD (regression coefficient, ß (SE); EI, 4.276 (0.921), p < 0.001; FOHR, 4.199 (0.844), p < 0.001; CA, 4.754 (1.458), p = 0.002; CH, 3.864 (0.874), p < 0.001; THW, 2.500 (1.132), p = 0.030).

Conclusion: Our data demonstrated a negative effect of the larger ventricle on treating PD patients who were void of evident ventriculomegaly. A larger dimension of the cerebral ventricle might predict poor treatment benefit and prognosis in PD.

« Back to 2023 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/effect-of-ventricular-morphometrics-on-the-treatment-of-parkinsons-disease/