Objective: To study features of cognitive symptoms in PD, depending on the severity of the disease.

Background: Parkinson’s disease (PD) is shown a wide range of mental disorders, including cognitive, affective, behavioral and psychotic disorders. Psychiatric disorders play a crucial role in the structure of the clinical manifestations of this pathology. So, depression and cognitive disorders are among the major factors that determine the quality of life of patients.

Methods: The research is based on survey data, 58 patients (36 women and 22 men) with Parkinson’s disease without dementia. Verification of the diagnosis carried out in accordance with the ICD-10, heading for a special code BP – G20. We analyzed the clinical stage and the rate of disease progression to determine the presence of postural instability and violations of walk, the distribution of symptoms identified in the limbs, the severity of cognitive impairment (on a scale MMSE), depression (on a scale of Wakefield). The average age of patients was 59,8 ± 1,2 years, variation number ranged from 50 to 65 years. The duration of illness averaged 3,8 ± 0,2 years of age.The control group consisted of 15 healthy persons matched for sex and age with the main group.

Results: According to clinical stage and rate of disease progression by Hyun and Yar (1967) Stage 1 PSU was set at 41.4% (24) patients with stage 2 BP – 36.2% (21 patients) and Stage 3 BP – from 22.4 % of patients (13). We obtained the following data characterizing the emotional disorders in patients with PD. The average level of depression in PD was 27,9 ± 0,5 points. The normal value of this indicator in the control group was 12 ± 0,2 points. Average depression in patients with 1 tbsp BP was -27,4 ± 0,5 points, with 2 tbsp. BP – 32,4 0,6 points, whereas in Article 3. BP, the figure rose to 35 ± 0,4 points. In patients with PD, there is an increase in the level of depression, depending on the progression of the disease. The assessment of cognitive status was carried out by a short scale MMSE. In the control group of mental status indicators on the MMSE showed the amount of points equal to 29,5 ± 0,1, which was close to that of normal (30 points). In all patients, patients with PD score was equal to 23,6 ± 0,1 (P <0,001).

Conclusions: Thus, anxiety and depression, cognitive impairment are recorded regularly in patients suffering from Parkinson’s disease. Intensity of these syndromes depends on the stage of PD and its progression.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/cognitive-impairment-in-parkinsons-disease/