Objective: To study the level of glial neurotrophic factor in the blood plasma depending on the duration of PD.

Background: Study of the biochemical aspects of Parkinson’s disease (PD) is an actual problem of modern neurology

Method: The material of this study was 78 patients with of PD. Duration of the disease – is 0.5 to 7 years. The control group consisted of 10 patients without symptoms of PD; Determines the content of glial neurotrophic factor in the blood serum by enzyme immunoassay performed with specific test systems developed on the basis of appropriate monoclonal antibodies on the analyzer Hospitex Diagnostics, Italy according to the instructions supplied with the kit.

Results: The results show that if the duration of 6-7 year, the level of glial neurotrophic factor in the blood plasma was 25,12 pg/ml, if the duration of 4-5 year, the level of glial neurotrophic factor was 32,65 pg/ml and in the duration 2-4 years the level of glial neurotrophic factor was 45,35 pg/ml, and in the control group the level of protein in blood plasma was 73.558±8.2 pg/ml. The level of glial neurotrophic factor in the blood plasma of PD is dependent on the degree of neurodegeneration. Patients with Parkinson’s disease have a relatively high level of glial neurotrophic factor in the serum in the early stages of the disease

Conclusion: The level of glial neurotrophic factor in the blood plasma of PD does not only depend on the clinical manifestations, and also depends on the duration of the disease.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/level-of-glial-neurotrophic-factor-in-the-blood-plasma-depending-on-the-duration-of-parkinsons-disease/