Session Information
Date: Monday, June 20, 2016
Session Title: Surgical therapy: Parkinson's disease
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To provide a thorough assessment of the effects of unilateral Forel’s H campotomy on Parkinson’s disease patients.
Background: Since its proposal in 1963, Forel’s H campotomy has been rarely performed to control Parkinson’s disease symptoms. Moreover, specific analyses on gait, axial motor symptoms, quality of life and cognitive functions were never performed.
Methods: Eleven right-handed Parkinson’s disease patients underwent unilateral Forel’s H campotomy. Assessments were performed before, six months and two years after surgery using the Unified Parkinson’s disease Rating Scale part III (UPDRS III), the motor tests of the core assessment program for intracerebral transplantation (CAPSIT) and the Unified Dyskinesia Rating Scale (UDysRS). Quality of life was estimated through the Parkinson’s disease quality of life questionnaire (PDQ-39). A comprehensive neuropsychological evaluation was performed.
Results: After two years, significant motor improvement occurred in off-medication condition as revealed by reduction of the UPDRS III (F=46.70; P=0.0001), the axial symptoms (F=18.75; P=0.0001) and gait (F=19.73; P=0.0001). The following CAPSIT variables also improved: walking time (F=13.27; P=0.0006), number of steps (F= 14.52; P=0.0004) and worst upper limb movements (F=9.42; P= 0.0063). Dyskinesia was seen in 6 patients and reduced 60% (F=13.50; P=0.0003). There was a tendence to decline in verbal categorical fluency (P=0.068). Executive function and attention declined as assessed by the Frontal Assessment Battery (P=0.0002) and the Stroop test (p=0.0313) scores. Quality of life improved 35.5% (p=0.0007). The sub-item Cognition of the PDQ-39 remained stable and no patient complained about cognitive deficit after surgery. Transient somnolence occurred in four patients. There was no changes in Levodopa-daily dose.
Conclusions: Unilateral Forel’s H campotomy provided significant motor and quality of life improvement with minimal cognitive impairment after 2 years follow-up.
To cite this abstract in AMA style:
F. Godinho, M.O. Oliveira, P. Terzian, C. Costa, P. Gordon, M.S. Rocha. Two years after unilateral Forel’s H campotomy for Parkinson’s disease: Quality of life, motor and cognitive outcomes of eleven patients [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/two-years-after-unilateral-forels-h-campotomy-for-parkinsons-disease-quality-of-life-motor-and-cognitive-outcomes-of-eleven-patients/. Accessed November 22, 2024.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/two-years-after-unilateral-forels-h-campotomy-for-parkinsons-disease-quality-of-life-motor-and-cognitive-outcomes-of-eleven-patients/