Session Information
Date: Monday, June 20, 2016
Session Title: Surgical therapy: Parkinson's disease
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: Because subthalamic nucleus deep brain stimulation is effective in L-3,4-dihydroxyphenylalanine responsive patients with Parkinson’s disease (PD), the preoperative catecholamine levels may affect the effect of subthalamic stimulation. Subthalamic stimulation may also influence the postoperative catecholamine levels.
Background: We aimed to examine the correlation between the preoperative catecholamine levels and postoperative clinical outcome. We also examined how catecholamine levels were modulated after subthalamic stimulation.
Methods: In total, 25patients with PD were enrolled (Mean age 66.2 ± 6.7 years, mean disease duration 11.6 ± 3.7 years). Mean levodopa equivalent doses were 1032 ± 34.6 mg before surgery. Cerebrospinal fluid and plasma catecholamine levels were measured an hour after oral administration of antiParkinsonian drugs before surgery. The mean Unified Parkinson’s disease Rating Scale scores and the Parkinson’s disease Questionnaire-39 were obtained before and after surgery. Of the 25 patients, postoperative cerebrospinal fluid and plasma were collected an hour after oral administration of antiParkinsonian drugs during on stimulation at follow up in 11 patients.
Results: Mean levodopa equivalent doses significantly decreased after surgery with improvement in motor functions and quality of life. The preoperative catecholamine levels had basically negative correlations with postoperative motor score and quality of life. The catecholamine levels were maintained postoperatively in 11 patients despite the significant reduction in levodopa equivalent doses. 
Conclusions: The preoperative catecholamine levels might affect the postoperative motor symptoms and quality of life. The catecholamine levels were not significantly reduced postoperatively despite the significant reduction in levodopa equivalent doses.
To cite this abstract in AMA style:
T. Yamamoto, T. Uchiyama, Y. Higuchi, M. Asahina, S. Hirano, Y. Yamanaka, S. Kuwabara. Subthalamic nucleus deep brain stimulation modulate catecholamine levels with significant relations to clinical outcome after surgery in patients with Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/subthalamic-nucleus-deep-brain-stimulation-modulate-catecholamine-levels-with-significant-relations-to-clinical-outcome-after-surgery-in-patients-with-parkinsons-disease/. Accessed November 22, 2024.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/subthalamic-nucleus-deep-brain-stimulation-modulate-catecholamine-levels-with-significant-relations-to-clinical-outcome-after-surgery-in-patients-with-parkinsons-disease/