Objective: The aim of this work was to study the potential clinical usefulness of the phase-amplitude coupling (PAC) between beta power and high frequency oscillations (HFO´s).

Background: Adaptive deep brain stimulation (aDBS) based on beta hypersynchrony has been introduced into clinical practice recently in Parkinson´s disease (PD). However, many other oscillopathies accompany the disease and beta power sensing is not optimal for all patients.

Method: Subthalamic nucleus (STN) local field potentials (LFP´s) from externalized DBS electrodes were recorded and analyzed in PD patients (n=11). Fluctuations in beta power were evaluated in resting state condition, then the phase-amplitude coupling (PAC) with high frequency oscillations (HFO´s) during low and high beta power episodes were studied and correlated with the electrode contact positions.

Results: Beta- HFO´s PAC (mainly in 200-400Hz range) was observed in all subjects. PAC was significantly stronger during high beta power episodes compared to low beta power sections. Moreover, this PAC was detectable also in contacts located within the STN, where beta power was not so prominent.

Conclusion: Coupling between beta power and HFO´s increases with the beta power synchronization, which is known to be a correlate of PD off state. Beta- HFO´s PAC seems to be more sensitive than beta power fluctuations itself and could be helpful in the best stimulation contact clinical selection or also as potential future input signal for aDBS.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/phase-amplitude-coupling-between-beta-power-and-high-frequency-oscillations-as-a-sensitive-marker-of-parkinsonian-state/