Objective: In this prospective cross sectional case control study, we have investigated the relationship of serum levels of Neurofilament light chain and Insulin like growth factor -1 with the type of Progressive Supranuclear Palsy and their impact on disease severity in a well characterized cohort of 40 PSP patents

Background: Several biomarkers have been explored in PSP. The levels of NFL were reportedly elevated 2-5 times more in patients of PSP compared to the controls. Insulin like growth factor 1 is hormone that has both endocrine and autocrine effects on various parts of brain. The levels of IGF1 are decreased with the age suggesting its possible role in neurodegenerative pathology

Method: Serum NFL and IGF 1 levels were measured in a cohort of 40 PSP patients who were diagnosed and classified according to MDS PSP diagnostic criteria and 40 age and gender matched healthy controls using commercially available ELISA kits. The study period was from November 2019 to November 2021. A detailed clinical evaluation was performed, and severity was assessed by various rating scales. The study was approved by the Institute ethics committee and funded by ICMR thesis grant no – MD20JUN-0065(DATE-02.09.2020).

Results: In our cohort five clinical variants were identified using MDS PSP criteria. The most common variant was PSP RS (n-27) followed by PSP P(n-10). One case each of PSP- F, PSP PAGF and PSP with SL were identified. The median levels of serum NFL in PSP patients (93.9 pg/ml (Q1, Q3-30.1,125.0)) were significantly elevated (p=0.001) compared to the controls 33.99 pg/ml (27.0, 43.9). There was no statistical difference in NFL levels between the groups PSP RS and PSP P(p=1.0). The median levels of IGF1 in patients with PSP (62.14 pg/dl (Q1, Q3 22.95, 45.8) were significantly lower compared to the controls (119.3 pg/dl (Q1-93.2, Q3-159.3)) (p= 0.017). There were no significant correlations of the serum NFL and IGF1 levels with the PSP variant, duration and severity of the illness.

Conclusion: The serum NFL levels can be considered as a reliable biomarker to differentiate PSP from the controls. However, its utility as a marker for prognosis and to differentiate PSP variants is still uncertain. Serum levels of IGF1 were significantly low in patients compared to the controls suggesting impaired regenerative function and its role in the pathophysiological mechanism of PSP

« Back to 2022 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/explorative-study-of-analysis-of-the-role-of-nfl-and-igf1-in-indian-patients-with-psp-and-its-clinical-correlation/