Category: Neuroimaging (Non-PD)
Objective: Providing a comprehensive literature review of resting-state brain connectivity alterations using resting-state fMRI (rs-fMRI) in hyperkinetic movement disorders (HMD). We additionally discuss alterations from the perspective of brain networks, as well as correlations between connectivity and clinical measures.
Background: HMD are commonly encountered disorders manifesting as abnormal and uncontrollable movements. Despite reported involvement of several neural circuits, exact connectivity profiles remain largely elusive.
Method: A systematic review was performed according to PRISMA guidelines and searching PubMed until November 2021. Studies using rs-fMRI to investigate ataxia, chorea, dystonia, myoclonus, tics, tremor, and functional movement disorders (FMD) were included.
Results: Most articles were on patients with tremor (45), followed by dystonia (37), tics (18), myoclonus (10), FMD (9), chorea (9), and ataxia (7). Altered resting-state connectivity was found in several brain regions: in ataxia it was mainly in cerebellar areas; for chorea, the caudate nucleus; for dystonia, sensorimotor and basal ganglia regions; for myoclonus, cortical regions (primary motor and cingulate cortex) and the thalamus; in tics, the basal ganglia, cerebellum, insula, and frontal cortex; for tremor, the cerebello-thalamo-cortical circuit; finally, in FMD, frontal, parietal, and cerebellar regions. Notably, both decreased and increased connectivity were found for all HMD. Correlations between clinical measures of motor severity and resting-state connectivity were frequently described.
Conclusion: An overview of key brain regions contributing to functional connectivity changes across HMD is provided. In all HMD, multiple, sometimes overlapping, brain regions were shown. Moreover, possible increases and decreases of functional connections of a specific region emphasizes the notion that HMD should be viewed as a network disorder. Despite the complex interplay of factors, including differences in methodologies used and how brain regions interact, this review can serve as a background to gain insight in commonalities and differences in brain connectivity profiles across HMD phenotypes.
To cite this abstract in AMA style:
R. Marapin, H. vd Horn, A. vd Stouwe, J. Dalenberg, B. de Jong, M. Tijssen. Altered Brain Connectivity in Hyperkinetic Movement Disorders: Systematic Review of Resting-State fMRI Studies [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/altered-brain-connectivity-in-hyperkinetic-movement-disorders-systematic-review-of-resting-state-fmri-studies/. Accessed September 7, 2024.« Back to 2022 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/altered-brain-connectivity-in-hyperkinetic-movement-disorders-systematic-review-of-resting-state-fmri-studies/