Objective: The background of our study was the presence or absence of changes in motor and non-motor disorders in patients with Parkinson’s syndrome of various origins after mild or moderate COVID-19.

Background: In our opinion, patients with Parkinson’s syndrome of various origins had different manifestations of complications of the transferred COVID-19. Our research has shown this.

Method: We studied 150 patients (97 men and 53 women), 58 – 75 years old, with Parkinson’s syndrome, Hoehn & Yahr, scale 0.5 – 1,5points. Group 1 (50 people) included patients with early stages of Parkinson’s disease with a disease duration of 1 to 4 years. Group 2 (50 people) included patients with vascular parkinsonism after a cerebral stroke from 3 months to 2 years ago. Group 3 (50 people) were patients with drug-induced parkinsonism who took drugs containing amlodipine or nimodipine from 1 to 5 years for hypertension. All patients have experienced COVID-19, alpha, delta, omicron, or multiple variants. We selected patients with mild to moderate COVID-19 without the need for hospitalization. All patients were examined: PCR, examination by an infectious disease specialist, examination by a neurologist. All patients received basic medication, depending on the prevailing symptoms.

Results: According to our results, in the 1st group, patients did not have a pronounced change in the clinic of both motor and non-motor (smell, insomnia, asthenia, depression, constipation) disorders. These patients did not require a pronounced correction of medication and rehabilitation. In group 2, there was a tendency to increased formation of micro- and macrothrombus, which was confirmed by coagulogram and ultrasound. Motor manifestations increased to Hoehn & Yahr scale 1 – 1,5 – 2 points. This required dose adjustment of L-DOPA and correction of medication with thrombolytics and disaggregants. In the 3rd group, patients had negative dynamics of the underlying disease, uncontrolled values of blood pressure. There was an increase in trembling, as well as severe asthenia, myalgia, headaches, increased constipation and sleep disorders. It required correction of antihypertensive therapy, as well as treatment of motor and non-motor disorders.

Conclusion: In our opinion, patients with Parkinson’s syndromes of different genesis who have undergone COVID-19 have a difference in complications that require different ways of treatment and rehabilitation.

References: –

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MDS Abstracts - https://www.mdsabstracts.org/abstract/comparison-of-complications-of-post-covid-19-in-patients-with-parkinsonism-syndrome-of-different-genesis/