Objective: We aimed to test the differences of dynamic regional homogeneity (dReHo) between PD patients and healthy controls (HCs), and explore whether dReHo can be utilized to distinguish PD from HCs and further investigate pathophysiological mechanisms of PD.

Background: Only little attention has been paid to the dynamic alterations of regional brain activity in Parkinson disease (PD).

Method: We finally included 57 PD patients and 31 HCs with rs-fMRI scans and neuropsychological examinations. Then dReHo was calculated in all the subjects. We compared dReHo between the PD patients and HCs, then the associations between dReHo variability and clinical/neuropsychological measurements were analyzed. The support vector machines (SVMs) was also used to assist differentiating PD patients from HCs, with the classification values of dReHo.

Results: The variation coefficient (CV) of dReHo was increased considerably in the precuneus in PD patients compared with HCs, and the CV of the dReHo in the precuneus was found to be highly associated with HAMD, HAMA, and NMSQ scores. Using the leave-one-out cross-validation procedure, 98 percent (p <0.001) of the individuals were properly identified using the SVM classifier.

Conclusion: These results provide new evidence for the aberrant resting-state brain activity in the precuneus of PD patients, and its role in neuropsychiatric symptoms in PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/temporal-dynamic-alterations-of-regional-homogeneity-in-parkinsons-disease-a-resting-state-fmri-study/