Objective: To report novel, real-world use of chronic local field potential (LFP) sensing in patients with Parkinson’s disease (PD) outside-of-clinic settings.

Background: Recent advancements in deep brain stimulation (DBS) technology have enabled clinicians to identify, measure, and chronically track LFPs in patients.

Method: Two patients with subthalamic nucleus (STN) DBS for PD, who were implanted with a neurostimulator capable of chronic LFP sensing, were included in this study as part of Medtronic’s Product Surveillance Registry. Clinician specified 5Hz wide frequency bands of interest were identified within the clinic, to enable at home tracking. Raw LFP data was collected at 250Hz, converted to frequency power spectra and consecutive 10 min average measures of the predefined band were stored. Tracking frequencies included multiple ranges (i.e., theta/alpha, beta, and gamma). LFP data was characterized using mean, standard deviation, and interquartile range across different stimulation amplitudes, and time of day (night (11pm-7am) and day (7am-11pm)). The relative difference between the mean of the LFP magnitudes during the night and day were calculated for each amplitude of stimulation.

Results: In Patient 1, LFP recordings were initiated 1 month after lead implantation and collected over 8 weeks. Multiple stimulation parameters (Current(C): Left Hemisphere: 0-2.4mA, Right Hemisphere: 0-0.7mA; Pulse Width (PW): 60µs, Frequency(F): 130Hz) and LFP frequencies (theta/alpha, beta, and gamma) were recorded from the bipolar contact pair 1-3. In Patient 2, stimulation and LFP recordings of the right hemisphere from contact pairs 0-2 of beta (22.46Hz) were initiated 3.3 years after lead implantation and collected over 3.5 weeks. The left hemisphere was excluded due to ECG artifact. Multiple stimulation parameters (Right
Hemisphere C: 1.9-2.1mA; PW: 90µs; F: 180Hz) were utilized. Mean LFP magnitudes during the day were higher than at night across all stimulation parameters and tracking frequencies (Patient 1: 64-40% on left-right; Patient 2: 35% on the right). [Table 1.]

Conclusion: These patient cases demonstrate real-world, novel utilization of chronic LFP sensing in patients with PD at multiple frequency bands and stimulation parameters. Additionally, this is one of the first reports of circadian rhythm effect on LFP power spectra using chronic, outside-of-clinic LFP sensing in PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/local-field-potential-recordings-in-parkinsons-disease-at-home-a-case-series-report/