Objective: To identify objectively the change in motor symptoms in a patient with Parkinson’s Disease (PD) on levodopa-carbidopa intestinal gel (LCIG) treatment with and without normal functioning in home environments with a wearable inertial device.

Background: LCIG is a second-line therapy which provides demonstrated benefits in quality of life in patients with PD. However, therapy management and supervision are complex and the evaluation of the therapy results frequently relies on patient’s opinion. STAT-ON is a medical device which provides objective information about the severity and distribution of PD motor symptoms in home environments.

Method: STAT-ON is recommended to a patient reporting a significant worsening with LCIG therapy after 4 months of good clinical response. The etiology was an spontaneous bad placement of the duodenal tube. We evaluated data report from STAT-ON before and after its normal positioning.

Results: Two STAT-ON reports were obtained: pre and post-LCIG tube adjustment. After setting the LCIG tube correctly, patient’s motor symptoms improved significantly. The patient shifted from 4.6 freezing of gait episodes to 1 episode per day and walked 12.4 minutes more each day (26% more than before). Also, the patient took 1,392 more steps per day on average. A total of 43.2% of inactivity was reported after the tuning against the 58.4% before the setting up. Both OFF and ON times slightly increased due to the patient’s activity.

Conclusion: STAT-ON was useful to quantify a wrong LCIG tube positioning, as well as PD motor symptoms. After adjusting the LCIG tube correctly, STAT-ON reported a significant improvement in different clinical aspects. Usefulness has been shown to quantify patient’s motor symptoms improvements due to the LCIG therapy and while being monitored in a home environment.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/use-of-a-wearable-medical-device-for-lcig-tube-adjustment-a-user-case/