Objective: The therapeutic effects of Hibiscus sabdariffa (HS) were investigated in parkinsonism rats induced by 6-hydroxydopamine (6-OHDA).

Background: The oxidative stress is an important component of the pathogenesis of PD. It has been shown that oxidative stress to dopaminergic neurons of substantia nigra is believed to be one of the leading causes of neurodegeneration in PD. Here, we hypothesised that Hibiscus sabdariffa would exert positive effects on motor dysfunction and brain oxidative stress.

Method: Rats were orally administered once per day for fourteen consecutive days different doses of HS prior to 6-OHDA lesion in the striatum. The control group rats were given the same volume of saline (vehicle) and followed the same schedule. Then, the potential neuroprotective effect of HS was done using neurobehavioral and neurochemical parameters.

Results: Oral administration of HS before 6-OHDA lesioning significantly reduces the amphetamine-induced rotation and increases spontaneous locomotor activity. Treatment with HS restored the level of GSH and partially restored the impairments of the level of SOD, CAT in striatum when compared to the control group.

Conclusion: Our results suggest that HS exerts neuroprotective effects against 6-OHDA-induced degeneration of the nigrostriatal dopaminergic system, suggesting that possibly daily intake of HS may slow down the PD progression.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/protective-effects-of-hibiscus-sabdariffa-extracts-in-6-hydroxydopamine-lesioned-parkinsonism/