Objective: We studied the effect of APOE ε4 carriers and non-carriers on clinical and motor functions in patients with IPD

Background: The significance of APOE genotype in patients with Parkinson’s Disease (PD) is controversial, but some authors suggest association of APOE e4 allele with dementia; while It’s effect on the motor symptoms is unclear.

Method: This study included 50 patients fulfilled the criteria for diagnosis of IPD based on British Brain Bank criteria.
Patients were divided into 2 groups:
Group I: included 22 patients with IPD and ε4 carrier (ε2/4, ε3/4 & ε4/4)
Group II: included 28 patients with IPD and non ε4 carrier
All patients were submitted to:
UPDRS
MRI brain
APOE Genotyping: APOE

Results: Most of the patients were APOE ε3/3 and ε3/4 genotype [Table 1].
The mean age at onset of disease was statistically significant (P=0.018) earlier in Group I patients compared to Group II [Figure 1].
The mean duration of illness was lower in Group I patients compared to Group II; but no statistically significant difference was detected.
Regarding the Predominant Type of symptoms: tremor predominant type was more in both Group I & Group II compared to Rigidity predominant type; with no statistically significant difference between both groups [Figure 2].
Although the UPDRS-Total was worse in Group I patients compared to Group II patients with mean score of 41.4 & 38.5 respectively, no statistically significant difference was detected [Figure 3].

Conclusion: APOE ε4 carriers is associated with earlier age of PD onset.
There was little evidence to support an association between APOE ε4 carriers and severity of motor features.

References: 1. Masatoshi Takeda, Rocío Martínez, Takashi Kudo, et al.,: Apolipoprotein E and central nervous system disorders: Reviews of clinical findings. Psychiatry and Clinical Neurosciences 2010; 64: 592–607.
2. Radka Pavlova, Shima Mehrabian, Maria Petrova, et al.,: Cognitive, Neuropsychiatric, and Motor Features Associated With Apolipoprotein E e4 Allele in a Sample of Bulgarian Patients With Late-Onset Parkinson’s Disease. American Journal of Alzheimer’s Disease & Other Dementias® 1-6, 2014.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/evaluation-of-genetic-influence-of-apoe-on-clinical-and-motor-functions-among-idiopathic-parkinsons-disease-patients-a-comparative-study/