Objective: Psychiatric tests evaluating symptoms such as depression, anxiety, rumination, obsession, impulsivity, apathy and impulsive compulsive behaviors were applied in patients with early onset PD. Clinical symptoms ,disease disability and the relationship between nonmotor symptoms and test results were evaluated.

Background: Psychiatric sympoms related with disease severity and occurs in early stages of disease.

Method: The study included 22  Idiopathic Parkinson’s Disease  patients with an age onset of 46.9 ± 7.4 (28-58) in the Movement Disorders Polyclinic of Health Sciences University Haydarpasa Hospital, Neurology Clinic  . Also 22 healthy individuals with mean age 48.5 ± 5.7 were included. Patients with treatment-related dyskinesia, who have motor fluctuations, on-off periods and psychosis and taken psychiatric treatment for any reasons were not included in the study. Early-onset Parkinson’s patients in stages 1, 2 Hoehn and Yahr were evaluated. Mini Mental Test , Beck Anxiety-Depression Scale , Barratt Impulsivity Scale, Ruminative Reactions Scale , Apathy Rating Scale , Parkinson’s Disease Impulsive Compulsive Diseases Scale , Maudsley Obsessive Compulsive Question List  was applied. Disease disability was measured by UPDRS.Nonmotor Symptoms Scale (NMSS), Nonmotor Symptoms Disability Assessment Scale (NMSDS) were applied.

Results: It was observed that  while NMSS, NMSDS, and as the levels of rumination and obsession compulsion increasing, the disease disability (UPDRS) was increased. NMSS score increased, disability increased, and the obsessive compulsive and ruminative thought scores were higher. UPDRS scores were higher at moderate and high level anxious patients .Depression, anxiety, obsession and rumination scale scores were higher in patients who takes L-dopa treatment . The relationship between L dopa and impulsive-compulsive state could not be detected.

Conclusion: In PD, nonmotor symptoms seen from the beginning of disease , can often be overlooked, can change disease severity and  effİciency of treatment.In our study, psychiatric symptoms present since onset of  disease were questioned with specific tests, and degree of nonmotor symptoms was determined with NMSDS through anamnesis and examination. Thus, we wanted to determine the presence of psychiatric symptoms and emphasize the effectiveness of these nonmotor symptoms in the disease disability in the early period .

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MDS Abstracts - https://www.mdsabstracts.org/abstract/effects-of-psychiatric-tests-on-disease-severity-and-nonmotor-symptoms-in-early-onset-parkinsons-disease/