Objective: The aim of this study is to evaluate the results of brain single photon emission computed tomography (SPECT) with 123-iodine ioflupane in patients with brain tumor treated with radiotherapy (RT).

Background: SPECT with 123-iodine ioflupane (DaTscan) is a presynaptic dopaminergic imaging. DaTscan allows to evaluate the nigrostriatal function and it is useful to differentiate Parkinson’s disease from non-degenerative akinetic-rigid syndromes.

Method: Retrospective study in thirty-two patients with akinetic-rigid syndrome and brain tumor treated with radiotherapy. All these patients underwent DaTscan imaging. Striatal uptake asymmetry was considered pathological for nigrostriatal involvement. The side of pathological striatal, the field of RT and the presence of parkinsonism-inducing drugs (PID) were analyzed.

Results: DaTscan was pathological in 16 cases (50%). Of these patients, the side of pathological striatal was concordant with the field of RT in 14 cases (88%) and PID was observed in 3 cases (19%). DaTscan was normal in 16 cases (50%). Of these patients, PID was observed in 4 cases (25%).

Conclusion: Nigrostriatal involvement is presented in half of these patients. The side of pathological striatal is concordant with the field of RT in practically all cases, so the akinetic-rigid syndrome is secondary to RT in these patients. There is no relationship between the taking of PID and the result of the DaTscan.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/brain-spect-in-patients-with-akinetic-rigid-syndrome-secondary-to-radiotherapy/