Objective: To evaluate, summarize and discuss the available literature concerning the potential effect of physical exercise on serum a-klotho levels in people with Parkinson’s disease.

Background: Parkinson’s disease is a progressive neurodegenerative disease that affects movement. The pathogenesis of Parkinson’s disease is mediated by different inflammatory mediators such as TNFα, IL‐1β, and IL‐6. In addition, the brain and kidneys are produced transmembrane molecules called Klotho. Several lines of evidence revealed that loss of Klotho may negatively impact the aging process, neural degeneration, and cognitive impairment in people with Parkinson’s disease. Indeed, Klotho molecules are playing an important role as anti‐inflammation and provide a protective effect against age‐related diseases such as Parkinson’s disease. Different lines of evidence suggests that physical activity may exert curative effects in Parkinson’s disease, slowing the underlying neurodegeneration and improving related disability symptoms.

Method: A comprehensive computer-based literature search was performed through MEDLINE database.

Results: The current evidence shows that regular physical activity plays a key role in the secreted form of the α-Klotho gene (S-Klotho) in animal models as well as in healthy humans. However, the current literature lacks clinical studies investigating the impact of physical activity on serum a-klotho levels in people with Parkinson’s disease. Despite that, previous clinical studies in healthy people and animal models showed a promising result in favour of physical activity. For example, previous studies demonstrating increased serum a-klotho levels in response to long-term exercise and to acute, high-intensity exercise.

Conclusion: Physical activity is a highly effective way of treating and preventing the main causes of morbidity and mortality, most of which are associated with aging. The absence of effective treatments for Parkinson’s disease highlights the need for preventive strategies such as physical activity. Thus, Physical activity may fill this gap and improve the levels of serum a-klotho levels in people with Parkinson’s disease. Future clinical studies are required to investigate the potential impact of physical activity on serum a-klotho levels in people with Parkinson’s disease.

« Back to MDS Virtual Congress 2021

MDS Abstracts - https://www.mdsabstracts.org/abstract/the-potential-impact-of-physical-activity-to-increase-serum-a-klotho-levels-in-people-with-parkinsons-disease/