Objective: Our data show that increasing plasma concentrations of the hormone of the stress-implementing system-cortisol, as well as dysfunctional disorders of the hormonal status characterizing thyroid function it is much more common in children and adolescents with complex motor tics that capture several muscle groups at the same time and coprolalia than in patients with simple motor tics in the form of twitching in one of the muscle groups and simple vocalisms in the form of separate sounds.

Background: The clinical efficacy of the treatment of Tourette’s disease is much faster and in a larger percentage of patients with hormonal profiles have been studied. Use of antihypoxants in the complex treatment of Tourette’s disease contributes to a more complete and rapid reduction of not only tics, but also psycho-pathological disorders in the form of anxiety, depressive manifestations, and social adaptation disorders, which, apparently, is associated with the optimization of neuro-endocrine interactions.

Method: We conducted a simple, randomized, comparative study in parallel groups. The average age of the subjects was 14.7 + 2.8 years. Mental status was evaluated by the frequency of occurrence and the severity of the main psychopathological symptoms. Hormonal profile was studied by ELISA. Plasma concentrations of the pituitary-adrenocorticotropic, thyroid-stimulating thyroid glands — thyroxin, adrenal hormone – cortisol, antibodies to myeloperoxidase and thyroglobulin were studied.

Results: The clinical efficacy of the treatment of Tourette’s disease is much faster and in a larger percentage of patients with hormonal profiles that are close in their values ​​to the control group of donors. It is important to note that these differences are apparently independent of anti-psychotic treatment. Use of anti-hypoxants in the complex treatment of Tourette’s disease contributes to a more complete and rapid reduction of not only tics, but also psycho-pathological disorders in the form of anxiety, depressive manifestations, and social adaptation, which, apparently, is associated with the optimization of neuro-endocrine interactions.

Conclusion: The high prevalence of clinical thyroid dysfunction and the overproduction of cortisol in patients with more severe manifestations of Tourette disease is an important factor for both clinical management and pathophysiological understanding of mechanisms of the disease.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/endocrine-predicts-of-the-formation-of-complex-motor-tics-in-tourettes-disease/