Session Information
Date: Thursday, June 23, 2016
Session Title: Other
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To determine the extent to which cortical epileptic foci of patients with comorbid psychogenic non-epileptic and epileptic seizures (PNES/ES) differ from age- and gender-matched ES patients without PNES and whether the clinical features of PNES/ES patients differ from PNES-only patients.
Background: Patients with combined PNES/ES provide a unique window into the neurobiology of functional disorders. The features that render ES patients vulnerable to developing comorbid PNES are unclear.
Methods: We retrospectively evaluated the clinical and electrographic features of 138 patients (105 women [77.1%]) from seven participating epilepsy centers with electroencephalography (EEG)-confirmed dual PNES/ES (n = 46; 38.87 ± 11.75 years), age- and gender-matched to PNES-only (n = 46; 38.93 ± 11.47 years) and ES-only patients (n = 46; 39.28 ± 11.43 years). Group differences were assessed using a logistic regression analysis after adjusting for clustering effect.
Results: Compared with ES-only patients, PNES/ES patients had longer seizure duration (p=0.007) with more epileptic activity in the right hemisphere (60.87% vs. 41.3%; p=0.060), and less in the left temporal lobe (15.22% vs. 34.78%; p=0.030). Compared to ES, patients with PNES/ES showed more “disorganized/unclear” EEG patterns, less absence/staring epileptic patterns (p=0.004) and higher depression and anxiety scores (p=0.006 and 0.004, respectively).
Conclusions: Right-hemispheric seizures were more common in patients with combined PNES/ES, supporting a neurobiological basis for functional complications in organic disorders.
To cite this abstract in AMA style:
B.D. Wissel, A.K. Dwivedi, T.E. Gaston, F.J. Rodriguez-Porcel, D. Al Jaafari, J.L. Hopp, A. Krumholz, Y. Wang, S.M.A. van der Salm, D.M. Andrade, F. Borlot, B.D. Moseley, J.L. Cavitt, S. Williams, J. Stone, W.C. LaFrance Jr, J.P. Szaflarski, A.J. Espay. Psychogenic non-epileptic seizures among patients with temporal lobe and other epilepsies: Phenomenology and EEG correlates [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/psychogenic-non-epileptic-seizures-among-patients-with-temporal-lobe-and-other-epilepsies-phenomenology-and-eeg-correlates/. Accessed September 7, 2024.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/psychogenic-non-epileptic-seizures-among-patients-with-temporal-lobe-and-other-epilepsies-phenomenology-and-eeg-correlates/