Category: Surgical Therapy: Parkinson's Disease
Objective: With this study, we wanted to demonstrate a new strategy to adjust stimulation parameters and lead configurations, using a visual analog scale.
Background: Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of Parkinson’s disease, essential tremor, anddystonia. In addition to the accurate electrode placement, effective programming of DBS devices is considered the most important factor for the individual patient outcome. Despite established strategies for adjusting neurostimulation, DBS programming remains time-and resource-consuming. Although kinematic and neuronal biosignals have recently been examined as potential feedback signals for closed-loop DBS (CL-DBS), there is an ongoing need for programming strategies to adjust stimulation parameters and lead configurations in a precise and yet effective manner.
Method: Here, we tested the usefulness of a patient-rated visual analog scale (VAS) for real-time adjustment of DBS parameters. The stimulation parameters (contact and amplitude) in Parkinson’s patients with STN-DBS (n = 17) were optimized based on the patient’s subjective VAS rating. A Minkowski Metric was calculated to compare the individual combination of contact selection and amplitude to the stimulation parameters that resulted from classical programming based on clinical signs and symptoms.
Results: We found no statistically significant difference between VAS-based and classical programming in regard to the specific contact or amplitude used or in regard to the clinical disease severity (UPDRS).
Conclusion: Our data suggest that VAS-based and classical programming strategies both lead to similar short-term results. Although further research will be required to assess the validity of VAS-based DBS programming, our results will support the investigation of the patient’s rating as an additional valid feedback signal for individualized DBS adjustment.
To cite this abstract in AMA style:
C. Palleis, M. Gehmeyr, J. Mehrkens, K. Boetzel, T. Koeglsperger. Establishment of a Visual Analog Scale (VAS) for DBS Programming (VISUAL – STIM Trial) [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/establishment-of-a-visual-analog-scale-vas-for-dbs-programming-visual-stim-trial/. Accessed November 25, 2024.« Back to MDS Virtual Congress 2020
MDS Abstracts - https://www.mdsabstracts.org/abstract/establishment-of-a-visual-analog-scale-vas-for-dbs-programming-visual-stim-trial/