Objective: To correlate and to compare changes on the lipid profile (LP) and on the body fat mass in people with Parkinson’s disease (PD) submitted to three physical therapy interventions: Dance [figure 1], Deep Water Running [figure 2], and Nordic Walking [figure 3].

Background: In addition to motor symptoms, is common to observe in PD the presence of elevated lipid profile [1], [2]  and body fat mass [3], [4]. Regular physical activity such as dance (DG) [5], deep water running (DWR) [6], and Nordic walking (NW) [7] can contribute to promote changes in lipid profile and body fat mass in people with PD.

Method: Subjects were 30 adults of both sexes, 68±11 years, with clinical diagnosis of PD, 17±7.32 UPDRS III, stages between 1 to 4 at Hoehn and Yahr Scale (H&Y). The subjects were divided in three groups: DG = 10, DWR =10, and NW = 10. The interventions lasted 24 sessions, 60 minuts each, for 3 months, 2 times / week. Venous blood samples were drawn into 4-mL EDTA anticoagulant tubes following at least 10-h overnight fasting. Tubes were centrifuged and plasma aliquots were frozen at -20 ºC for further analysis. Total cholesterol (CHO), high-density lipoprotein (HDL) and triacylglycerol levels (TGL) were measured using an automated analyzer (Cobas C111, Roche Diagnostics, Basel, Switzerland), while low-density lipoprotein (LDL) was calculated by the Friedewald equation. The dual energy X-ray absorptiometry (DEXA – Lunar Prodigy Model GE Medical System, Milwaukee, WI, USA) was used to evaluate body fat mass (BFM). Descriptive statistics (mean and standard deviation) were estimated to characterize the subjects. Generalized Estimating Equations (GEE) analysis was used to compare the DG, DWR and NW, pre and post intervention, α <0.05. The Spearman and the Pearson test were performed to verify the correlation between BFM and HDL, LDL, CHO and TGL (α <0.05, SPSS).

Results: The pre and post interventions comparison are presented in Table [table 1]. A low correlation between BFM x CHO (d = 0.24), BFM x LDL (d = 0.18), BFM x HDL (d = 0.14) and BFM x TGL (d = 0.18) were found. Significant differences were found on BFM in DWR group (p=0.02), decreasing the values, and in the HDL (p=0.00) and TGL (p=0.01) in NW group, increasing the values.

Conclusion: Despite a low correlation between LP and BFM, significant changes were observed on these outcomes in DWR and in NW walking group.

References: 1 – De Lau, L. M., et al.; (2006). Serum cholesterol levels and the risk of Parkinson’s disease. American journal of epidemiology, 164(10), 998-1002. 2 – Ruipérez, V., et al.; (2010). Alpha-synuclein, lipids and Parkinson’s disease. Progress in lipid research, 49(4), 420-428. 3 – Revilla, M., et a. ; (1998). Body composition in Parkinson’s disease: a study with dual-energy X-ray absorptiometry. Parkinsonism & related disorders, 4(3), 137-142. 4 – Petroni, M. L., et al.; (2003). Body composition in advanced-stage Parkinson’s disease. Acta Diabetologica, 40(1), s187-s190. 5 – dos Santos Delabary, M., et al. (2018). Effects of dance practice on functional mobility, motor symptoms and quality of life in people with Parkinson’s disease: a systematic review with meta-analysis. Aging clinical and experimental research, 30(7), 727-735. 6 – Pinto, C., et al.; (2018). Is hydrotherapy effective to improve balance, functional mobility, motor status, and quality of life in subjects with Parkinson’s disease? A systematic review and meta-analysis. PM&R. 7 – Monteiro, E. P. et al.;(2017). Effects of Nordic walking training on functional parameters in Parkinson’s disease: a randomized controlled clinical trial. Scandinavian journal of medicine & science in sports, 27(3), 351-358.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/correlation-and-comparison-of-the-lipid-profile-and-the-body-fat-mass-in-people-with-parkinsons-disease-submitted-to-three-physical-therapies/