Objective: Today, the use of medicinal herbs to prevent and slow down the progression of Parkinson’s disease has attracted the attention of researchers. The phenolic compounds in plants are secondary metabolites that, by inhibiting oxidation, cause the removal of free radicals, and the use of these antioxidants in the diet plays an important role in the prevention of chronic diseases due to oxidative stress.

Background: Parkinson’s disease is a central nervous system disorder in older adults, characterized by “progressive muscle stiffness, shake, and loss of motor skills. After Alzheimer’s disease, Parkinson’s disease is the most common malignant neurological disease. Parkinson’s symptoms appear in both physical and psychological categories, with apparent symptoms such as motionlessness, slowness of movement, muscle stiffness, resting tremors, and decreasing reflexes. Olive leaf extract contains various phenolic compounds that induce various pharmacological effects.

Method: In this study, 60 small mice were randomly selected and were assigned in 6 groups including control, control, levodopa and 3 groups receiving the hydroalcoholic extract of olive leaf in three doses of 50,100 and 200 mg/kg of mice weight. All groups except the control group received paroxetine for 19 hours at subcutaneous intervals of 48 hours. After induction of Parkinson’s, the drug group received levodopa ½ mg/kg of mice weight, and the extract groups received intraperitoneal injection in three doses of 50, 100 and 200 mg/kg of mice, respectively, and 55 minutes after injection, each mice was individually evaluated behavioral by both Rearing tests (frequency of standing on two legs in a cylinder) and a bar test (keeping the bar 10 cm), and standard assessment indicators checked through the review and recorded.

Results: The results were analyzed using a statistical package in the social sciences. The results show that extract in a dose of 100 mg/kg of mice weight in bar test compared with the drug group and other doses of the extract significantly increased the holding time of the bar by the mouse, indicating a reduction in the symptoms of Parkinson’s.

Conclusion: Based on the results, it seems that the hydroalcoholic extract of the olive leaf with a dose of 100 mg/kg of mice weight can be considered as a suitable alternative to levodopa in reducing Parkinson’s symptoms.

References: Ahmadi Ahangar A, Sadraei Mousavi A R. Comparison of the Effect of Bromocriptine and Selgin on the Treatment of Parkinson’s disease. Journal of Babol University of Medical Sciences, 2002; 3: 18-22. Rahimi A, Khosrowbakhsh F, Isadpanah A, Hasanzadeh K. 2013. Induction of Parkinson’s disease Model by Ruthenone in Rat. Journal of Isfahan Medical School, 2013; 32: 296-312. Akramian Fard M.؛ Moghaddam A. 2015. Effects of Achillea millefolium aqueous extract in a Parkinson’s disease model induced by intra-cerebral-ventricular injection of 6-hydroxydopamine in male rats. Journal of Sabzevar University of Medical Sciences. 2015; 22(1): 36-44. Safari M, Badban L, Sameni H, Bandegi A, Rashidypour A, Vafaei A. Comparison the protective effects of aqueous extract of Iranian propolis in 6-hydroxydopamine-induced model of parkinsonism in male rat with L-DOPA: A behavioral and histological evaluation. koomesh. 2014; 15 (4): 584-591.

« Back to MDS Virtual Congress 2020

MDS Abstracts - https://www.mdsabstracts.org/abstract/comparison-of-the-effect-of-hydroalcoholic-extract-of-olive-leaf-and-levodopa-on-reducing-parkinsons-symptoms-in-animal-model/