Objective: We evaluate the Parkinson`s disease patients with very slow progression. One of their clinical features are the medical history of tumor.

Background: Some cancer gene have effects on Parkinson`s disease progression. For example, PIEZO1, TRAPPC2L, and SOX6 have effects on  both melanoma and Parkinson`s disease. LRRK2 (Parkinson`s disease related gene) increased risks of leukemia as well as skin and colon cancers. But most neurologists think patients with Parkinson`s disease had lower  cancer risk. Parkin is identified as a gene implicated in autosomal recessive Parkinsonism. Several evidences indicate that Parkin is a tumor suppressor gene, involved in a variety of cancers. A Double-Edged Sword: Parkison’s disease progression and cancer suppression. So very slow progression of Parkinson`s disease may mean weak effects of tumor suppression.

Method: This is the single center, retrospective study. We examined medical records of our outpatients with Parkinson’s disease.

Results: Three Parkinson`s disease patients with very slow disease progression are enrolled.They don`t have dementia. They can walk without no walking aids after 12 years after disease onset. They have tumors with no symptom. Their tumors were all detected by annual medical checkup. They have no chief complaint about tumor. Patient 1: 72-year-old man: Gastric cancer (adenocarcinoma) 4 years before Parkinson`s disease onset. Patient 2: 80-year-old man: double cancer. Lung cancer (adenocarcinoma) 10 years before Parkinson`s disease onset. Duodenum neuroendocrine tumor 9 years after Parkinson`s disease onset. Patient 3: 67-year-old man: Colon polyps 11 years after Parkinson`s disease onset. Family history of lung cancer.

Conclusion: If we find the Parkinson`s disease patients with very slow progression, we should actively make effort to detect tumors.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/relationship-between-tumor-and-very-slow-parkinsons-disease-progression/