Objective: To review non-motor symptoms of PD with RBD, To explore the effects of RBD on PD.

Background: Non-motor symptoms of PD with RBD were different from those without RBD.

Method: This article is based on relative literature and original articles retrieved by a PubMed search.

Results: 1.Cognitive impairment
Compared to those without RBD, cognitive impairment was more serious in PD with RBD, and the incidence of mild cognitive impairment was higher. Also, the severity of cognitive impairment was positively correlated with the severity of RBD symptoms.
2.Depression and anxiety
PD with RBD showed serious depression and anxiety. It was concluded that RBD may exacerbate depression and anxiety by affecting sleep quality. Also, dose of antidepressants in PD with RBD was much more than that in PD without RBD. In conclusion, RBD could aggravate depression and anxiety in PD, otherwise antidepressants lead to RBD.
3.Hallucinations
PD with RBD were likely to experience hallucinations. PGO wave was a kind of brain wave with certain frequency and amplitude that produced by ponto-geniculo-occipital in pons during REM sleep, which  could regulate sleep structure. Dreams and visual hallucinations were associated with PGO waves. Thus more hallucinations in PD with RBD may be related to terrible REM period in RBD.
4.Autonomic function
PD with RBD were more likely to develop autonomic dysfunction such as hypotension, constipation, urinary system dysfunction and sexual dysfunction. Generally, overlap was founded between sleep regulation area of REM period and autonomic regulation area in brain stem. Due to dysfunction of this region, the REM period was disordered, as well as affecting the regulation of autonomic function.
5.Impulse control disorders(ICD)
PD who practice dopamine receptor agonist treatment were likely to lead to ICD. It was believed in some researches that RBD was not related to ICD in PD. However, others showed that PD with RBD had a higher incidence of ICD. It seems that more researches would be necessary in this aspect.
6.The others
Hyposmia and sleep disorders were more common and worse in PD with RBD.

Conclusion: Cognitive impairment, depression and anxiety, hallucinations, autonomic dysfunction, hyposmia and sleep disorders were more serious in PD with RBD than those without RBD. More researches would be necessary between ICD and RBD in PD.

« Back to MDS Virtual Congress 2020

MDS Abstracts - https://www.mdsabstracts.org/abstract/the-clinical-features-of-non-motor-symptoms-in-parkinsons-disease-with-rapid-eye-movement-sleep-behavior-disorderrbd/