Objective: This study is to explore the relationship between the rs442495 and rs593742 loci of ADAM10 gene and Parkinson’s disease( PD) or PD cognitive impairment.

Background: Recently, two meta-analysis of large genome-wide association studies has identified rs442495 and rs593742 of ADAM10 gene as two novel risk loci for Alzheimer’s disease (AD). ADAM10 is a α-secretase contributing to cleave the ectodomain of TREM2 which is closely related to Parkinson’s disease (PD). However, the association between polymorphism of ADAM10 gene and PD and PD with cognitive impairment is unknown.

Method: A total of 335 Chinese patients with PD and 362 age- and sex- matched healthy controls from Guangdong Provincial People’s Hospital. Among them, there are 248 PD patients completing cognitive evaluation. PD patients were divided into PD with normal cognition (PD-NC) and PD with mild cognitive impairment (PD-MCI) according to the Level II criteria of 2012 Movement Disorder Society (MDS) Task Force Guidelines.The SNaPshot single nucleotide polymorphism (SNP) genotyping technique was used to genotype rs442495 and rs593742 of ADAM10 gene. And we further analyze the association between rs442495 and rs593742 loci in PD and PD-MCI in Chinese population.

Results: There was no statistical difference in the distribution of age and sex between PD patients and controls as well as in the age between PD-NC, PD-MCI and healthy controls (Table 1, 2). However, there were statistical difference in the sex between PD-NC, PD-MCI and healthy controls(p=0.04) (Table 2). No differences in genotype or allele frequencies were observed between PD and HC group with regard to the investigated polymorphisms in the genotype of rs442495 (C/T) （genotype p=0.909,allele p=0.664）and rs593742 (A/G) （genotype p=0.554,allele p=0.285）of ADAM10 gene (Table 3). Similarly, Genotype and allele of rs442495 （genotype p=0.993,allele p=0.978）and rs593742 （genotype p=0.377,allele p=0.131）were no significantly difference between PD-NC, PD-MCI and healthy controls (Table 4).

Conclusion: The study suggested that rs442495 and rs593742 of ADAM10 gene are not a genetic risk factor for PD and PD with cognitive impairment.

« Back to MDS Virtual Congress 2020

MDS Abstracts - https://www.mdsabstracts.org/abstract/adam10-polymorphisms-are-not-associated-with-susceptibility-to-parkinsons-disease-and-parkinsons-disease-with-cognitive-impairment-in-a-chinese-cohort/