Session Information
Date: Wednesday, September 25, 2019
Session Title: Neuroimaging
Session Time: 1:15pm-2:45pm
Location: Les Muses Terrace, Level 3
Objective: To investigate the cortical thickness, surface area and subcortical volumes changes in the fronto-parietal cortices and subcortical structures, and to obtain a representative model of areas involved to predict the severity of symptoms in Parkinson’s disease patients with freezing of gait.
Background: Previous functional neuroimaging studies have implicated the frontoparietal and frontostriatal dysfunction in the pathophysiology of freezing of gait in Parkinson’s disease, however, the extent of anatomical changes remains unclear.
Method: Forty Parkinson’s disease patients with freezing of gait, 31 without freezing of gait, and 30 normal controls were enrolled in the study. Whole brain structural imaging was performed on a SIEMENS Trio 3T scanner. Surface-based investigation of cortical thickness and surface area in 98 fronto-parietal gyrus and sulcus areas, and brain volumes in subcortical regions were carried out by using Freesurfer. Between-group differences and a combined Least Absolute Shrinkage and Selection Operator regression to predict freezing of gait severity were performed.
Results: Between-group differences showed focal cortical thinning in bilateral precentral gyrus, and reduced volume in the right putamen in Parkinson’s disease patients with freezing of gait compared to those without. No significant differences were found after Bonferroni correction in the comparisons between the two Parkinson’s disease groups with normal controls. Combined Least Absolute Shrinkage and Selection Operator regression demonstrated that cortical thickness in the bilateral precentral gyrus and interm_prim-Jensen syrus, surface area in the left parietal inferior gyrus, right frontal inferior gyrus, right orbital syrus, and subcortical volume in the right putamen, pallidum, thalamus could predict the freezing of gait score with a correlation of 0.927 (p＜0.001).
Conclusion: Frontoparietal anatomical changes and freezing of gait in Parkinson’s disease are detectable and clearly related.
To cite this abstract in AMA style:
T. Mi, S. Garg, A. Liu, P. Chan, M. Mckeown. Patterns of cortical thickness, surface area and subcortical volume in Parkinson’s disease patients with freezing of gait [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/patterns-of-cortical-thickness-surface-area-and-subcortical-volume-in-parkinsons-disease-patients-with-freezing-of-gait/. Accessed November 21, 2024.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/patterns-of-cortical-thickness-surface-area-and-subcortical-volume-in-parkinsons-disease-patients-with-freezing-of-gait/