Objective: The objective is to study the relation between cognitive impairment with the form and stage of PD.

Background: Currently, there is a tendency of a global change in the gender and age structure of the population. The proportion of older people in the population is steadily increasing. Cognitive impairment is directly related to age. So from the age of 65 their prevalence doubles every 5 years. Parkinson’s disease plays a big role in the development of dementia.

Method: 287 patients with PD I-IV stage of Hyun and Yar  took part in the study. The average age of the patients is 66.4 ± 9.0 years. All received standard specific anti-parkinsonian pharmacotherapy.  All patients have been evaluated according to the Mini-Mental State Examination (MMSE), the clock-drawing test (CDT) and the Frontal Assessment Batte (FAB).

Results: On the FAB scale, the maximum average was observed in patients with stage I of PD – 15.6 ± 2.6 points and the minimum with stage IV – 13.0 ± 4.1 points. A similar tendency was also revealed when performing the CDT test, where the highest result was observed at stage I of the disease – 8.8 ± 1.7 points, and the lowest at stage IV – 5.9 ± 2.6 points. Patients with a tremor of PD had the highest results of neuropsychological testing and the largest number (45.8%) of people without cognitive impairment (p <0.0001) were recorded, with mixed ones - lower (p <0.0001).

Conclusion: The study has demonstrated that the patients with a tremor of PD had less of their severity cognitive impairment compared with mixed form of PD. Patients with stage I of PD had minimal the severity of cognitive impairment.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/cognitive-impairment-in-patients-with-parkinsons-disease/